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首页> 外文期刊>Journal of clinical neuromuscular disease >Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP): A Review of Clinical Syndromes and Treatment Approaches in Clinical Practice
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Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP): A Review of Clinical Syndromes and Treatment Approaches in Clinical Practice

机译：慢性炎症脱髓鞘PolyradiculoneCathy（CIDP）：临床实践中临床综合征及治疗方法的综述

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摘要

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a chronic, acquired immune and inflammatory disorder of the peripheral nervous system. The classic form of the disorder is manifested by progressive or relapsing proximal or generalized limb weakness and areflexia, and usually easily recognized; it is the large number of regional and functional variants and variety of associated illnesses that pose a challenge to the clinician in practice. Similarly, laboratory and electromyography criteria have been developed to confirm the diagnosis; however, these various schemes are contrived because only 50% to 60% of patients with typical clinical features of CIDP fulfill these strict electrodiagnostic research criteria. Several studies have established the efficacy of immune therapies such as corticosteroids, plasma exchange, and intravenous immune globulin as the mainstay of treatment of CIDP, but these treatments might provide only short-term benefit. This review offers an approach to the evaluation and management of patients with CIDP and highlights the difficult clinical problems in those who do not respond or frequently relapse after treatment with standard therapies such as patients with CIDP and concomitant axonal loss, and the assessment of those with CIDP and concurrent diseases such as diabetes mellitus.
机译：慢性炎症脱髓鞘（CIDP）是慢性，获得的外周神经系统的免疫和炎症疾病。通过渐进或复发近端或广义的肢体弱点和令人难以容易认识到近端或普遍的肢体的经典形式。它是大量的区域和功能变体和各种相关疾病，在实践中对临床医生构成挑战。类似地，已经开发了实验室和肌电图标准以确认诊断;然而，这些各种方案都是有价值的，因为只有50％至60％的CIDP典型临床特征的患者符合这些严格的电压电压研究标准。一些研究已经建立了免疫疗法如皮质类固醇，血浆交换和静脉内免疫球蛋白的疗效，作为CIDP的主要疗法，但这些治疗可能只提供短期效益。本综述提供了一种方法，提供了一种CIDP患者的评估和管理，并突出了在用CIDP患者等标准疗法治疗后没有反应或经常复发的那些困难的临床问题，以及伴随的轴突丧失，以及评估那些CIDP和并发疾病，如糖尿病。

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