...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>AIDS >The effects of HIV and combination antiretroviral therapy on white matter integrity
【24h】

The effects of HIV and combination antiretroviral therapy on white matter integrity

机译：HIV和抗逆转录病毒疗法联合治疗对白质完整性的影响

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: HIV preferentially affects white matter in the brain. Although combination antiretroviral therapy (cART) reduces HIV viral load within the brain, continued inflammation can persist. We investigated the effect of HIV and cART on white matter integrity. Design: We used diffusion tensor imaging (DTI) to examine the effects of HIV and cART on white matter integrity within the corpus callosum and centrum semiovale (CSO). Methods: Neuropsychological testing and DTI measures (fractional anisotropy, mean diffusivity, axial diffusivity, radial diffusivity) were obtained from 21 HIV-uninfected controls, 21 HIV-infected patients naive to cART (HIV +cART-), and 21 HIV+ patients receiving stable cART (HIV +cART+). A subset of the HIV +cART-individuals (n=10) was assessed before and 6 months after receiving medications. Differences among the cross-sectional groups were assessed using an analysis of variance, whereas paired t-tests evaluated longitudinal changes. Results: HIV +cART-participants had significantly lower mean diffusivity, axial diffusivity, and radial diffusivity for the corpus callosum and CSO compared to HIV-controls and HIV +cART+ individuals. No significant difference existed between HIV-controls and HIV +cART+ patients. cART initiation significantly improved mean diffusivity, radial diffusivity, and axial diffusivity, but not fractional anisotropy, in the corpus callosum and CSO in some HIV-infected patients. Conclusion: Observed decreases in DTI parameters between HIV +cART+ and HIV +cART-individuals could reflect the presence of inflammatory cells or cytotoxic edema in HIV +cART-patients. Initiating cART could lead to a reduction in neuro-inflammation and improvement in DTI measures. Future DTI studies may be useful for evaluating the efficacy higher brain penetrating cART regimens.
机译：目的：艾滋病毒会优先影响大脑中的白质。尽管联合抗逆转录病毒疗法（cART）可以减少大脑中的HIV病毒载量，但持续的炎症仍会持续。我们调查了HIV和cART对白质完整性的影响。设计：我们使用扩散张量成像（DTI）来检查HIV和cART对call体和中心半卵白质（CSO）中白质完整性的影响。方法：从21名未感染HIV的对照组，21名未接受cART的HIV感染患者（HIV + cART-）和21名获得稳定的HIV +患者中获得了神经心理学测试和DTI指标（分数各向异性，平均扩散率，轴向扩散率，径向扩散率）购物车（HIV + cART +）。在接受药物治疗之前和之后6个月评估了一部分HIV + cART个人（n = 10）。使用方差分析评估横断面组之间的差异，而配对t检验评估纵向变化。结果：与HIV对照者和HIV + cART +个体相比，HIV体和CSO的HIV + cART参与者的平均扩散性，轴向扩散性和径向扩散性明显较低。 HIV对照和HIV + cART +患者之间没有显着差异。在某些感染了HIV的患者中，cART启动显着改善了call体和CSO中的平均扩散率，径向扩散率和轴向扩散率，但不改善分数各向异性。结论：观察到的HIV + cART +和HIV + cART个人之间DTI参数的降低可能反映了HIV + cART患者中存在炎症细胞或细胞毒性水肿。启动cART可以减少神经炎症并改善DTI措施。未来的DTI研究可能对评估高脑穿透性cART方案的疗效可能有用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号