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Replication of RYR3 gene polymorphism association with cIMT among HIV-infected whites

机译:在HIV感染的白人中RYR3基因多态性与cIMT的关联复制

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摘要

To replicate the association of variants in RYR3 gene with common carotid intima-media thickness (cIMT), a surrogate marker of atherosclerosis, we genotyped single nucleotide polymorphisms (SNPs) rs2229116 and rs7177922 in a sub-population of 244 HIV-positive and HIV-negative men. SNP rs2229116 was associated with common cIMT in HIV infected white men after adjusting for age and use of stavudine (d4T). The association was more evident at younger ages and decreased among older individuals.
机译:为了复制RYR3基因中的变体与动脉粥样硬化的替代标志物颈总动脉内膜中层厚度(cIMT)的关联,我们对244个HIV阳性和HIV-亚群中的单核苷酸多态性(SNP)rs2229116和rs7177922进行了基因分型消极的人。在调整年龄和司他夫定(d4T)的使用后,SNP rs2229116与HIV感染的白人男性中的常见cIMT相关。这种联系在年轻时更为明显,而在老年人中则下降。

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