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首页> 外文期刊>Journal of Clinical Pharmacy and Therapeutics >Effects of six types of aspirin combination medications for treatment of acute cerebral infarction in China: A network meta-analysis
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Effects of six types of aspirin combination medications for treatment of acute cerebral infarction in China: A network meta-analysis

机译：六种阿司匹林组合药物治疗中国急性脑梗死的影响：网络元分析

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摘要

What is known and objective Previous studies have shown that various aspirin combinations might be beneficial for the treatment of acute cerebral infarction (ACI). The aim of this study was to evaluate the efficacy of six aspirin combinations in the treatment of ACI using network meta-analysis (NMA). The performance of these combinations is then ranked according to results of this analysis. Methods Multiple databases were consulted to find randomized controlled trials (RCT) of six different aspirin combinations for the treatment of ACI. NMA was conducted on the data using stata (13.0) software. The odds ratio (OR) was calculated. The studies included in this paper were divided into a control group (aspirin alone) and an observation group (one of six aspirin combinations). Results A total of 103 eligible RCTs were identified. A total of 13 317 cases were included in the study, and the results showed that the six types of aspirin combinations (aspirin with atorvastatin, ozagrel sodium, low molecular weight heparin [LMWH], clopidogrel, cilostazol and ginkgo damo) were all significantly superior (P 0.05) to aspirin alone. The combination of aspirin with LMWH had the highest probability of being the most clinically efficacious intervention, with a surface under the cumulative ranking (SUCRA) curve of 79.1. The combination of aspirin with ozagrel sodium was the worst, with a SUCRA value of 29.7. What is new and conclusion A combination of aspirin with LMWH is the best option among the six aspirin combinations considered for the treatment of ACI. The combination of aspirin with ozagrel sodium was ranked the last
机译：已知和目的先前的研究表明，各种阿司匹林组合可能有利于治疗急性脑梗死（ACI）。本研究的目的是评估使用网络Meta分析（NMA）治疗ACI治疗ACI的疗效。然后根据该分析的结果对这些组合的性能进行排序。方法咨询多个数据库以查找六种不同阿司匹林组合的随机对照试验（RCT），用于治疗ACI。使用Stata（13.0）软件在数据上进行NMA。计算赔率比（或）。本文中包含的研究分为对照组（单独的阿司匹林）和观察组（六种阿司匹林组合之一）。结果共识别出103条合格的RCT。该研究中共有13例317例，结果表明，六种类型的阿司匹林组合（阿司匹林与阿司伐他汀，ozagrel钠，低分子量肝素[LMWh]，氯吡格雷，西洛塞唑和银杏）都显着优越（P＆ 0.05）单独服用阿司匹林。阿司匹林与LMWH的组合具有最高概率，最高概率是最临床有效的干预，表面下的累积排名（SUCRA）曲线为79.1。阿司匹林与ozagrel钠的组合是最糟糕的，Sucra值为29.7。什么是新的和结论阿司匹林与LMWh的组合是考虑治疗ACI的六种阿司匹林组合中的最佳选择。阿司匹林与ozagrel钠的组合排名最后

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    Jin Lairun; Zhou Jun; Shi Wei; Xu Liang; Sheng Jun; Fan Jingyi; Yuan Yuting; Yuan Hui;

  • 作者单位

    Wannan Med Coll Sch Publ Hlth Dept Epidemiol &

    Biostat 22 Rd Wenchangxi Wuhu 241002 Anhui;

    Wannan Med Coll Sch Publ Hlth Dept Epidemiol &

    Biostat 22 Rd Wenchangxi Wuhu 241002 Anhui;

    Wannan Med Coll Sch Publ Hlth Dept Epidemiol &

    Biostat 22 Rd Wenchangxi Wuhu 241002 Anhui;

    Wannan Med Coll Affiliated Yijishan Hosp Dept Rheumatol Wuhu Peoples R China;

    Wannan Med Coll Affiliated Yijishan Hosp Dept Rheumatol Wuhu Peoples R China;

    Wannan Med Coll Sch Publ Hlth Dept Epidemiol &

    Biostat 22 Rd Wenchangxi Wuhu 241002 Anhui;

    Wannan Med Coll Sch Publ Hlth Dept Epidemiol &

    Biostat 22 Rd Wenchangxi Wuhu 241002 Anhui;

    Wannan Med Coll Sch Publ Hlth Dept Epidemiol &

    Biostat 22 Rd Wenchangxi Wuhu 241002 Anhui;

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  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

    aspirin; cerebral infarction; efficacy; network meta-analysis; randomized controlled trials;

    机译：阿司匹林;脑梗死;疗效;网络元分析;随机对照试验;

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