The therapeutic phase I trial of the recombinant native HIV-1 Tat protein.

Ensoli B; Fiorelli V; Ensoli F; Lazzarin A; Visintini R; Narciso P; Di-Carlo A; Monini P; Magnani M; Garaci E

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The therapeutic phase I trial of the recombinant native HIV-1 Tat protein.

机译：重组天然HIV-1 Tat蛋白的治疗性I期试验。

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The native HIV-1 Tat protein was chosen as a vaccine candidate based on its key role in the virus life cycle and on the correlation of Tat-specific immune responses with the asymptomatic stage and lower disease progression rates, but also due to its sequence conservation amongst the various HIV clades as well as the adjuvant effects on dendritic cells. Safety, immunogenicity and efficacy data in monkeys support the development of this vaccine concept.

机译：基于天然HIV-1 Tat蛋白在病毒生命周期中的关键作用以及Tat特异性免疫反应与无症状阶段和较低疾病进展率之间的相关性，也由于其序列保守性，选择了该疫苗作为候选疫苗包括各种HIV进化枝以及对树突状细胞的佐剂作用。猴子的安全性，免疫原性和功效数据支持该疫苗概念的发展。

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来源
《AIDS》 |2008年第16期|共3页
作者
Ensoli B; Fiorelli V; Ensoli F; Lazzarin A; Visintini R; Narciso P; Di-Carlo A; Monini P; Magnani M; Garaci E;
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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
Proteins; HIV-1; Therapeutic; phase I study; 蛋白质类;

机译：Proteins;HIV-1;Therapeutic;phase I study;蛋白质类;

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1. 含HIV-1 Tat基因重组反转录病毒表达载体构建与表达Tat蛋白功能检测 [J] . 卢春, 钱超, 唐桂霞, 生物医学研究杂志（英文版） . 2003,第006期
2. The therapeutic phase I trial of the recombinant native HIV-1 Tat protein. [J] . Ensoli B, Fiorelli V, Ensoli F, AIDS . 2008,第16期

机译：重组天然HIV-1 Tat蛋白的治疗性I期试验。
3. Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial. [J] . Gilbert PB, Peterson ML, Follmann D, The Journal of Infectious Diseases . 2005,第5期

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4. Phase I therapeutic trial of the HIV-1 Tat protein and long term follow-up [J] . Longo O, Tripiciano A, Fiorelli V, Vaccine . 2009,第25a26期

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The therapeutic phase I trial of the recombinant native HIV-1 Tat protein.

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