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首页> 外文期刊>Journal of clinical anesthesia >The effect of morphine added to bupivacaine in ultrasound guided transversus abdominis plane (TAP) block for postoperative analgesia following lower abdominal cancer surgery, a randomized controlled study
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The effect of morphine added to bupivacaine in ultrasound guided transversus abdominis plane (TAP) block for postoperative analgesia following lower abdominal cancer surgery, a randomized controlled study

机译：随机对照研究后，随机对照研究，随机对照研究术后镇痛的超声引导横向肺腹腹（Tap）嵌段的影响。随机对照研究

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Abstract Objectives Transversus abdominis plane (TAP) block used for management of surgical abdominal pain by injecting local anesthetics into the plane between the internal oblique and transversus abdominis muscles. We aimed to explore the effect of adding morphine to bupivacaine in ultrasound guided TAP-block in patients undergoing lower abdominal cancer surgery. Study design Randomized, double-blind, prospective study. Clinical trial identifier: NCT02566096 . Setting Academic medical center. Patients Sixty patients were enrolled in this study after ethical committee approval. Interventions Patients divided into 2 groups (30 each): Bupivacaine group (GB): given ultrasound guided TAP-block 20 ml 0.5% bupivacaine diluted in 20 ml saline; Morphine group (GM): given ultrasound guided TAP-block with 20 ml 0.5% bupivacaine + 10 mg morphine sulphate diluted in 20 ml saline. Measurements Patients were observed for total morphine consumption, time for first request of rescue analgesia, sedation scores, hemodynamics and side effects for 24 h postoperatively. Results Morphine added to bupivacaine in TAP block compared to bupivacaine alone reduced total morphine consumption (5.33 ± 1.28 mg) (10.70 ± 3.09 mg) respectively (p 0.001), prolonged the time to first request of analgesia (10.40 ± 4.96 h) (6.97 ± 3.26 h) respectively (p 0.008), with a statistically significant decrease in (VAS-M) in GM compared with GB at 12 h postoperatively (p 0.002). No significant differences in hemodynamics, respiratory rate, oxygen saturation, sedation score, and side effects except for nausea were observed (p 0.05). Conclusion Addition of morphine to bupivacaine in TAP block is effective method for pain management in patients undergoing major abdominal cancer surgery without serious side effects. Highlights ? Transversus abdominis plane (TAP) block, formally documented by Rafi. ? TAP-block was a safe and effective postoperative analgesia method in a variety of surgeries. ? Opioids exert a local analgesic effect as based on several observations. ? Morphine addition to bupivacaine in TAP block is safe and effective method for postoperative pain.
机译：摘要目标通过将局部麻醉剂注入内倾斜和横向腹部肌肉之间的平面来管理外科腹部疼痛的横向倾盆大平面（TAP）块。我们的旨在探讨在腹部肿瘤癌手术患者中加入吗啡加入对蟾蜍群的武器卡因。学习设计随机，双盲，前瞻性研究。临床试验标识符：NCT02566096。设定学术医疗中心。患者在道德委员会批准后，患有六十名患者的患者。干预患者分为2组（每次30个）：Bupivacaine组（GB）：给定超声引导滴落块20mL 0.5％Bupivacain在20ml盐水中稀释;吗啡群（GM）：给定超声引导滴落块，20ml 0.5％Bupivacaine + 10mg吗啡硫酸盐在20ml盐水中稀释。观察到术语术后总体含量的患者，术后24小时的救援镇痛，镇静分数，血流动力学和副作用的时间。结果与海拔块加入的南锥盖的结果单独减少吗啡消费（5.33±1.28mg）（5.73±3.09mg）（P <0.001），延长了镇痛首次要求的时间（10.40±4.96小时） （P <0.008）分别（6.97±3.26小时），术后12小时的GB（P <0.002），GM中（VAS-M）的统计学上显着降低（P <0.002）。观察到除恶心外，血流动力学，呼吸速率，氧饱和度，镇静评分和副作用无显着差异（P＆ 0.05）。结论在Tap块中加入对蟾蜍群岛的加入是患者疼痛管理的有效方法，患者在没有严重副作用的情况下进行腹部癌症手术。强调 ？横向腹部飞机（Tap）块，由Rafi正式记录。还Tap-Block是各种手术中安全有效的术后镇痛方法。还阿片类药物根据几种观察结果发挥局部镇痛作用。还在Tap块中加入Bupivacaine的药物是术后疼痛的安全有效的方法。

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