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Balancing effectiveness and access to HIV treatment in the developing world.

机译:在发展中国家平衡有效性和获得艾滋病治疗的机会。

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摘要

In Cambodia, where 78% of people earn less than USdollar2 dollars per day, UNAIDS estimates that 130 000 people are currently infected with HIV; 16000 Cambodians have already died with HIV infection . Providing optimal treatment and care for large numbers of HIV-infected people is clearly a challenge in countries with limited resources. In this issue of AIDS, Madec and colleagues examined responses to HAART among 1735 severely immuno-compromised patients, who joined a Medecins Sans Frontieres-sponsored treatment access programme in Phnom Penh . The median CD4 cell count at initiation of HAART was 20 cells/mul, with 75% of patients starting with fewer than 78 cells/mul. Those with CD4 cell counts below 20 cells/mul at initiation of HAART had a 2-year mortality rate of 24.7%, versus 2-year rates of 4-7% for those with higher baseline CD4 cell counts. Those with missing CD4 cell counts at baseline (i.e. those .with very poor health status who did not need CD4 cell counts to decide on HAART initiation) hadthe highest mortality.
机译:在柬埔寨,有78%的人每天的收入不足2美元,联合国艾滋病规划署估计,目前有13万人感染了艾滋病毒。已有16000名柬埔寨人死于HIV感染。在资源有限的国家中,为大量艾滋病毒感染者提供最佳治疗和护理显然是一项挑战。在这一期的艾滋病中,马德茨及其同事检查了1735名严重免疫功能低下的患者对HAART的反应,这些患者参加了金边的无国界医生资助的治疗访问计划。 HAART启动时的CD4细胞中位数为20细胞/每人,其中75%的患者开始时少于78细胞/每人。在开始HAART时CD4细胞计数低于20细胞/ mul的患者的2年死亡率为24.7%,而基线CD4细胞计数较高的患者的2年死亡率为4-7%。基线时CD4细胞计数缺失的人(即那些健康状况非常差的人,不需要CD4细胞计数来决定是否进行HAART起始)的死亡率最高。

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