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首页> 外文期刊>The world journal of biological psychiatry: the official journal of the World Federation of Societies of Biological Psychiatry >Serum inflammatory molecules and markers of neuronal damage in alcohol-dependent subjects after withdrawal
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Serum inflammatory molecules and markers of neuronal damage in alcohol-dependent subjects after withdrawal

机译：血清炎症分子和戒断后的酒精依赖受试者的神经元损伤标记

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Objectives: Our aim is to describe changes in serum concentration for the pro-inflammatory factors TNF-alpha, IFN-gamma, IL-1 beta, IL-8, IL-6, IL-10, IL-12 and MCP-1, for the satiety factor leptin and for factors associated with neuronal changes, neuron-specific enolase (NSE) and glial activation S100-beta protein (S100-beta), and explore their association with abstinence in alcohol-dependent subjects after withdrawal. Methods: Serum sampling and clinical assessments from 115 alcohol-dependent subjects admitted to a psychiatric hospital for alcohol were repeated during the first 48 h of withdrawal (M0) and 1, 2, 4 and 6 months (M1, M2, M4 and M6) thereafter. Serum factors were determined with Luminex technology or by ELISA. Results: The levels of TNF-alpha, IL-1 beta, IL-8, IL-6, IL-12, MCP-1, and leptin decreased after withdrawal and remained low until M6, regardless of alcohol consumption. IFN-gamma levels remained constant and IL-10 levels changed only slightly. NSE levels were not modified, whereas serum S100-beta concentration increased significantly on M1 and then plateaued, regardless of abstinence status at 6 months. Conclusions: Alcohol-dependent subjects present an inflammatory condition that is not dependent on alcohol consumption. An understanding of the changes in concentration of the various proteins considered here would provide insight into the physiology of withdrawal or dependence.
机译：目的：我们的宗旨是描述血清血清浓度的变化TNF-α，IFN-Gamma，IL-1β，IL-8，IL-6，IL-10，IL-12和MCP-1，对于饱腹感瘦蛋白和与神经元变化相关的因素，神经元特异性烯醇化酶（NSE）和胶质激活S100-β蛋白（S100-β），并在戒断后探讨其含有酒精依赖性受试者的禁欲。方法：在戒断（M0）和1,2,4和6个月（M1，M2，M4和M6）的前48小时内，重复从115名饮酒依赖于酒精精神病医院接受醇的精神病医院的血清抽样和临床评估此后。用Luminex技术或ELISA测定血清因子。结果：在取出后，TNF-α，IL-1β，IL-8，IL-6，IL-12，MCP-1和瘦蛋白的水平降低，无论醇消耗如何，直至M6才能降低。 IFN-Gamma水平仍然恒定，IL-10级别仅略微改变。没有修饰NSE水平，而血清S100-β浓度在M1上显着增加，然后达到禁止禁止状态，而6个月。结论：酗酒的受试者呈现不依赖于酒精消耗的炎症病症。对这里考虑的各种蛋白质浓度变化的理解将提供对戒断或依赖的生理学的洞察力。

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