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首页> 外文期刊>Journal of drugs in dermatology: JDD >Beta-Blockers for Pyogenic Granuloma: A Systematic Review of Case Reports, Case Series, and Clinical Trials
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Beta-Blockers for Pyogenic Granuloma: A Systematic Review of Case Reports, Case Series, and Clinical Trials

机译:β-嵌体用于化脓性肉芽肿:系统报告,案例系列和临床试验的系统审查

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摘要

Pyogenic granuloma (PG) is an acquired vascular growth on the skin and mucous membranes. Even though PG is a benign tumor, treatment is required due to associated risk of ulceration and bleeding, cosmetic concerns, and the low likelihood of spontaneous regression. Treatment entails excisional surgery, cryotherapy, or electrocautery; recurrence however is a major problem. Beta-blockers became an attractive option for the treatment of vascular growths after it got approved for infantile hemangioma. PG was found to express beta adrenergic receptors, similarly to infantile hemangioma. Several publications have reported the use of oral and topical beta blockers such as timolol, propranolol, and betaxolol for the treatment of PG. In this study, we summarized the literature with regards to the effectiveness of topical beta blockers for the treatment of PG, and discussed all published case reports, case series, and open-label single arm trials.
机译:卵晶肉芽肿(PG)是皮肤和粘膜上获得的血管生长。 尽管PG是一种良性肿瘤,因此需要治疗,因为溃疡和出血,化妆品问题的危险风险,并且自发性回归的低可能性。 治疗需要切除外科,冷冻疗法或电陶工; 然而,再次发生是一个主要问题。 β-阻滞剂在批准婴儿血管瘤后治疗血管生长的含量有吸引力的选择。 发现PG表达β肾上腺素能受体,类似于婴儿血管瘤。 几种出版物据报道,使用口腔和局部β受体阻滞剂如蒂洛尔,普萘洛尔和甲状腺醇用于治疗PG。 在这项研究中,我们向文献总结了关于局部β受体阻滞剂的有效性,以治疗PG,并讨论了所有已发表的案例报告,案例系列和开放标签单手臂试验。

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