A Phase 2, Multicenter, Double-Blind, Randomized, Vehicle Controlled Clinical Study to Assess the Safety and Efficacy of a Halobetasol/Tazarotene Fixed Combination in the Treatment of Plaque Psoriasis

Sugarman Jeffrey L.; Gold Linda Stein; Lebwohl Mark G.; Pariser David M.; Alexander Binu J.; Pillai Radhakrishnan

首页> 外文期刊>Journal of drugs in dermatology: JDD >A Phase 2, Multicenter, Double-Blind, Randomized, Vehicle Controlled Clinical Study to Assess the Safety and Efficacy of a Halobetasol/Tazarotene Fixed Combination in the Treatment of Plaque Psoriasis

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A Phase 2, Multicenter, Double-Blind, Randomized, Vehicle Controlled Clinical Study to Assess the Safety and Efficacy of a Halobetasol/Tazarotene Fixed Combination in the Treatment of Plaque Psoriasis

机译：2阶段，多中心，双盲，随机，车辆控制的临床研究，以评估Halobetasol / Tazarotene固定组合在斑块牛皮癣的治疗中的安全性和疗效

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Background: Psoriasis is a chronic, immune-mediated disease that varies widely in its clinical expression. Treatment options focus on relieving symptoms, reducing inflammation, induration, and scaling, and controlling the extent of the disease. Topical corticosteroids are the mainstay of treatment, however long-term safety remains a concern, particularly with the more potent formulations. Combination therapy with a corticosteroid and tazarotene may improve psoriasis signs at a lower corticosteroid concentration providing a superior safety profile.

机译：背景：牛皮癣是一种慢性免疫介导的疾病，其临床表达中的巨大变化。治疗方案专注于缓解症状，减少炎症，硬结和缩放，并控制疾病的程度。局部皮质类固醇是治疗的主要支柱，但长期安全仍然是一个问题，特别是具有更有效的配方。用皮质类固醇和塔拉替烯的组合疗法可以在较低的皮质类固醇浓度下改善牛皮癣迹象，提供优异的安全性。

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来源
《Journal of drugs in dermatology: JDD》 |2017年第3期|共8页
作者
Sugarman Jeffrey L.; Gold Linda Stein; Lebwohl Mark G.; Pariser David M.; Alexander Binu J.; Pillai Radhakrishnan;
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作者单位

Univ Calif San Francisco San Francisco CA 94143 USA;

Henry Ford Hosp Detroit MI 48202 USA;

Icahn Sch Med Mt Sinai New York NY 10029 USA;

Virginia Clin Res Inc Norfolk VA USA;

North Amer LLC Valeant Pharmaceut Bridgewater NJ USA;

Dow Pharmaceut Sci Inc Petaluma CA USA;

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正文语种 eng
中图分类药学;
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1. A Phase 2, Multicenter, Double-Blind, Randomized, Vehicle Controlled Clinical Study to Assess the Safety and Efficacy of a Halobetasol/Tazarotene Fixed Combination in the Treatment of Plaque Psoriasis [J] . Sugarman Jeffrey L., Gold Linda Stein, Lebwohl Mark G., Journal of drugs in dermatology: JDD . 2017,第3期

机译：2阶段，多中心，双盲，随机，车辆控制的临床研究，以评估Halobetasol / Tazarotene固定组合在斑块牛皮癣的治疗中的安全性和疗效
2. Efficacy, Safety, and Tolerability of a Halobetasol 0.01% / Tazarotene 0.045% Fixed Combination in the Treatment of Severe Localized Plaque Psoriasis: Post Hoc Analysis of Two Phase III Randomized Controlled Trials [J] . Lebwohl Mark G., Sugarman Jeffrey L., Gold Linda Stein, Journal of drugs in dermatology: JDD . 2019,第10期

机译：卤代醇的功效，安全性和耐受性0.01％/达拉替烯0.045％固定组合在治疗严重局部斑块牛皮癣中：两期III阶段随机对照试验后的HOC分析
3. Safety and efficacy of a fixed combination of halobetasol and tazarotene in the treatment of moderate-to-severe plaque psoriasis: Results of 2 phase 3 randomized controlled trials [J] . Linda Stein Gold, Mark G. Lebwohl, Jeffrey L. Sugarman, Journal of the American Academy of Dermatology . 2018,第2期

机译：固定组合Halobetasol和Tazarotene在治疗中度至重度斑块牛皮癣中的安全性和功效：2相3随机对照试验的结果
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6. Safety and Efficacy of a Halobetasol 0.01/Tazarotene 0.045 Fixed Combination Lotion in the Treatment of Moderate-to-severe Plaque Psoriasis: A Comparison with Halobetasol Propionate 0.05 Cream [O] . Neal D. Bhatia, David M. Pariser, Leon Kircik, 2018

机译：0.01％/他扎罗汀0.045％他扎罗汀0.045％固定组合洗剂治疗中度至重度斑块状牛皮癣的安全性和有效性：与丙酸卤倍他索0.05％乳膏的比较
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机译：前瞻性，多中心，随机，双盲，车辆控制的第2期，用于评估3％米诺环素和0.3％氨基丙烯局部泡沫配方的组合的安全性和功效，用于治疗中度至严重的痤疮

A Phase 2, Multicenter, Double-Blind, Randomized, Vehicle Controlled Clinical Study to Assess the Safety and Efficacy of a Halobetasol/Tazarotene Fixed Combination in the Treatment of Plaque Psoriasis

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