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首页> 外文期刊>Journal of drugs in dermatology: JDD >Orf Virus Infection in Humans: A Review With a Focus on Advances in Diagnosis and Treatment
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Orf Virus Infection in Humans: A Review With a Focus on Advances in Diagnosis and Treatment

机译：人类中的ORF病毒感染：审查专注于诊断和治疗的进步

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摘要

Ecthyma contagiosum, also called contagious pustular dermatosis, is a zoonotic disease caused by the orf virus (OrfV). As a member of the poxviridae family and parapoxvirus genus, this.dermatotropic virus has developed an array of mechanisms by which to evade the host immune system in both humans and animals. The ubiquitousness of this pathogen in sheep, goats, and deer has led to the development of orf in diverse areas around the world. Human disease occurs via direct contact with infected animals or fomites. Rarely, human-to-human transmission has been reported. The disease progresses through six clinically distinct dermatologic stages and lesions usually heal in three to six weeks without scarring. Farmers, veterinarians, and hunters represent high-risk groups, as their repeated contact with livestock and wild animals predisposes them to infection. With an increasing number of cattle, livestock, and wild animals being kept as pets, human orf may become more prevalent in the future. Taken with the lack of a widely accepted and successful antiviral treatment regimen, this demonstrates the importance of conducting additional research to further elucidate the pathogenic effects of the OrfV in humans.
机译：Ecthyma contagiosum，也称为传染病脓疱性皮肤病，是由ORF病毒（ORFV）引起的一种动物疾病。作为Poxviridae家族和Parapoxvirus Genus的成员，This.Dermatropic病毒已经开发出一种机制阵列，用于避开人类和动物的宿主免疫系统。这种病原体在绵羊，山羊和鹿中的普遍存在，导致了世界各地各地的ORF的发展。人类疾病通过与受感染的动物或粉末直接接触而发生。很少地报告了人对人类传播。这种疾病通过六个临床不同的皮肤病学阶段进行，病变通常在三到六周内愈合而不会瘢痕。农民，兽医和猎人代表高风险群体，因为他们对牲畜和野生动物的反复接触，使他们感染。随着牛，牲畜和野生动物的越来越多，人类的ORF在未来可能变得更加普遍。随着缺乏广泛接受和成功的抗病毒治疗方案采取，这证明了进行额外研究的重要性，以进一步阐明orfv在人类中的致病作用。

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