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首页> 外文期刊>Journal of drugs in dermatology: JDD >Halobetasol 0.01% Lotion in the Treatment of Moderate-to-Severe Plaque Psoriasis of the Lower Extremities
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Halobetasol 0.01% Lotion in the Treatment of Moderate-to-Severe Plaque Psoriasis of the Lower Extremities

机译:Halobetasol 0.01%乳液治疗下肢中度至重度斑块牛皮癣

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摘要

Background: Psoriasis is a chronic, immune-mediated disease that varies widely in its clinical expression. Topical corticosteroids (TCS) are the mainstay of treatment. Long-term safety remains a concern, limiting use, and posttreatment flare is common. Recently data were reported on the use of halobetasol propionate (HP) 0.01 % lotion in moderate or severe localized plaque psoriasis, once-daily for 8 weeks. In addition, a 2-week label-restricted study reported comparable efficacy to HP 0.05% cream. Data evaluating efficacy in specific locations has not been reported and while psoriasis commonly affects lower extremities treatment can be more problematic and burden of disease heightened.
机译:背景:牛皮癣是一种慢性免疫介导的疾病,其临床表达中的巨大变化。 局部皮质类固醇(TCS)是治疗的主要支柱。 长期安全仍然是一个令人担忧,限制使用,并且后病理耀斑是常见的。 最近报告了在中等或严重局部斑块牛皮癣中使用Halobetasol丙酸盐(HP)0.01%乳液的使用,每日一次持续8周。 此外,2周的标签限制研究报告了HP 0.05%乳膏的相当疗效。 尚未报告评估特定位置的疗效,虽然牛皮癣通常影响下肢治疗可能会更加有问题,并且疾病的负担增强。

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