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首页> 外文期刊>Journal of cutaneous pathology >Low‐fat and fat‐free spindle cell lipomas in the oral cavity: Immunohistochemical analysis and review of the literature
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Low‐fat and fat‐free spindle cell lipomas in the oral cavity: Immunohistochemical analysis and review of the literature

机译：口腔中的低脂肪和无脂的主轴细胞Lipomas：文献的免疫组化分析和审查

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Abstract The low‐fat and fat‐free spindle cell lipomas (SCLs) are rare and often mistaken for other benign and malignant morphological mimics, because of the fact that the diagnosis relies on its non‐lipogenic component analysis. Here, we report the clinicopathological features of two oral SCLs (low‐fat and fat‐free variants). Both lesions presented clinically as an asymptomatic nodule, which initially yielded diagnostic difficulties on the morphological analysis alone. One case was diagnosed as low‐fat SCL on the lower lip in a 29‐year‐old man, and the other as fat‐free SCL on the buccal mucosa in a 46‐year‐old man. In both cases, immunohistochemistry showed strong positivity for CD34 and, remarkably, retinoblastoma (Rb) protein was deficient. Mast cell (MC) tryptase and toluidine blue stain highlighted numerous MCs distributed throughout all tumor stroma. Alpha‐SMA and desmin were negative. S100 evidenced scarce adipocytes only in the low‐fat SCL case. Conservative surgical treatment was performed and no recurrence was noticed in about 2‐year of follow‐up in both cases. Because of the potential pitfalls, careful morphological analysis of the tumor stroma in the low‐fat/fat‐free SCL diagnosis, supported by immunohistochemistry (especially CD34, Rb and MC tryptase), is strongly recommended. To the best of our knowledge, these are the first and second cases reported of fat‐free and low‐fat SCL in the oral cavity.
机译：摘要稀有的低脂肪和无脂的主轴细胞Lipomas（SCL）是罕见的，并且通常误认为是其他良性和恶性的形态模拟，因为诊断依赖于其非脂肪成分分析。在这里，我们报告了两种口服SCL的临床病理特征（低脂肪和无脂肪变种）。临床上呈现的两种病变作为无症状结节，其最初在单独的形态学分析上初始出现诊断困难。在一个29岁的男子中，一个病例被诊断为下唇的低脂SCL，另一个是一个46岁的男人在口腔粘膜上的脂肪SCL。在这两种情况下，免疫组织化学表现出CD34的强阳性，并且显着地，视网膜母细胞瘤（RB）蛋白缺乏。肥大细胞（MC）胰蛋白酶和甲苯胺蓝色染色突出了众多MCS在所有肿瘤基质中分布。 alpha-sma和desmin是消极的。 S100仅在低脂肪SCL案例中证明了稀缺性脂肪细胞。进行保守的手术治疗，在两种情况下，在大约2年后的后续行动中没有发生复发。由于潜在的缺陷，强烈推荐，仔细地对低脂肪/脂的SCL诊断中肿瘤基质的形态分析（特别是CD34，RB和MC胰蛋白酶）。据我们所知，这些是在口​​腔中报道的第一和第二次患者，在口腔中报道无脂肪和低脂肪SCL。

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