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首页> 外文期刊>Journal of cutaneous pathology >Hypergranulotic dyscornification: 30 cases of a striking epithelial reaction pattern
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Hypergranulotic dyscornification: 30 cases of a striking epithelial reaction pattern

机译：过度血管性渗滤装置：30例醒目上皮反应模式

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Abstract Background Hypergranulotic dyscornification (HD) is a rarely reported histological reaction pattern that may be observed in solitary benign keratoses. Objective and Methods We retrospectively reviewed all cases described as displaying “hypergranulotic dyscornification” at our institution between January 1st 1990 to September 1st 2018. We excluded cases that on retrospective review displayed changes of epidermolytic hyperkeratosis. We conducted electron microscopy (EM) of two lesions. Results Thirty cases were identified in our search. Eleven patients were men and 19 were women. Their mean age was 56.9 ± 21.2?years. In contrast to previous reports, we found that HD does not spare the head and neck area. Frequent clinical impressions were inflamed seborrheic keratosis, Bowen disease or inflamed verruca. The most distinctive histopathologic finding was the presence of a prominent granular layer with clumped perinuclear keratohyaline granules. Some cases had mounds of rounded, anucleate glassy eosinophilic corneocytes in the stratum corneum. We observed one case of incidental HD occurring in an epidermoid cyst. EM of HD showed dense perinuclear bands which appeared to match areas of positive staining by keratin immunohistochemistry, without evidence of pale cytoplasmic areas devoid of keratin filaments, characteristic of epidermolytic hyperkeratosis. Conclusion HD is a reproducible finding in some benign keratoses, probably because of abnormal keratinization. Awareness of this unique reaction pattern will help prevent misdiagnosis.
机译：摘要背景血液抑制（HD）是一种很少报道的组织学反应模式，其可以在孤独的良性角斑中观察到。目的和方法我们回顾性地审查了在1990年1月1日至2018年9月1日至9月1日在2018年至2018年9月展示了展示了“超高林信息化”的案例。我们排除了回顾性审查表现出表皮水解过度检测的情况。我们进行了两种病变的电子显微镜（EM）。结果我们的搜索中确定了30例。 11名患者是男性，19名是女性。他们的平均年龄为56.9±21.2？年。与以前的报告相比，我们发现HD不会避免头部和颈部区域。频繁的临床印象是发炎的甜食角化症，鲍文病或发炎的疣状。最鲜明的组织病理学发现是具有丛生的PerinucleclecleclecalclecleChyaline颗粒的突出颗粒层。有些病例有圆形的圆形，无核玻璃状嗜酸性玉米粒细胞中的角质层。我们观察了表皮样囊肿中发生的一种偶然的HD。 HD的em显示出致密的蠕变乐队，似乎匹配角蛋白免疫组织化学的阳性染色区域，没有易畸形细胞的浅色细胞质面积，表皮微粒胶质瘤的特征。结论HD是一些良性角度的再现发现，可能是因为角质化异常。对这种独特的反应模式的认识将有助于预防误诊。

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