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首页> 外文期刊>Journal of drug delivery science and technology >Facile green route synthesis of gold nanoparticles using Caulerpa racemosa for biomedical applications
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Facile green route synthesis of gold nanoparticles using Caulerpa racemosa for biomedical applications

机译：使用Caulerpa Racemosa进行生物医学应用的金纳米粒子的舒适绿色途径

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摘要

A green chemical approach to the synthesis of gold nanoparticles from the Caulerpa racemosa and its biomedical applications are reported. The C. racemosa mediated synthesized gold nanoparticles (Cr@AuNPs) were characterized by various spectral and microscopy techniques. The Cr@AuNPs exhibited a surface plasmon resonance (SPR) peak at 528 nm in UV-Vis spectrum. X-ray diffraction analysis confirmed the crystalline nature and face-centered cubic (fcc) structure of Cr@AuNPs. The presence of phytochemical constituents in the aqueous extract of C. racemosa that involves the major role in Cr@AuNPs synthesis which was confirmed by FT-IR analysis. Further, FESEM and HRTEM results confirmed that the Cr@AuNPs were spherical-to-oval in shape, and the size was ranged from 13.7 to 85.4 nm. The synthesized Cr@AuNPs effectively controlled the growth of human colon adenocarcinoma (HT-29) cells, and it exhibited the IC50 at 20.84 mu g/ml. Similarly, the green synthesized Cr@AuNPs demonstrated admirable antibacterial activity against A. veronii than S. agalactiae. Further, the synthesized Cr@AuNPs exhibited non-toxic effects on Artemia nauplii, even at high concentration of Cr@AuNPs (100 mu g/ml). The above findings deliver a strong basis for future studies into drug development for cancer and bacteria.
机译：报道了一种从Caulerpa Hatemosa合成金纳米粒子的绿色化学方法及其生物医学应用。通过各种光谱和显微镜技术，特征在于C. HACEMOSA介导的合成金纳米颗粒（CR / AUNP）。 Cr / aUnps在UV-Vis光谱中显示出528nm的表面等离子体共振（SPR）峰。 X射线衍射分析证实了Cr @ aUnps的结晶性质和面对面的立方（FCC）结构。在C.的植物提取物中存在植物化合物的存在，其涉及CR @ AUNPS合成中的主要作用，该综合由FT-IR分析证实。此外，FeSEM和HRTEM结果证实，CR @ AUNPS以呈球形到椭圆形，尺寸为13.7至85.4nm。合成的Cr / aUnps有效地控制了人结肠腺癌（HT-29）细胞的生长，并且它在20.84μg/ ml下表现出IC50。同样，绿色合成的Cr / auNPS对A. Veronii的令人钦佩的抗菌活性比S. Alacactiae展示。此外，合成的Cr / aUnps甚至在高浓度的Cr / aumps（100μg/ ml）的高浓度下表现出对Artemia Nauplii的无毒作用。上述调查结果为癌症和细菌的药物发育提供了强有力的基础。

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