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首页> 外文期刊>Journal of drug targeting >PRCosomes: pretty reactive complexes formed in liposomes
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PRCosomes: pretty reactive complexes formed in liposomes

机译：prcosomes：脂质体中形成的相当反应复合物

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As a tribute to Pieter R. Cullis, this manuscript identifies a liposomal formulation that bears his initials: the PRCosomes. Pretty Reactive Complexes within liposomes were observed, while the senior author of this manuscript completed his Ph.D. thesis under Pieter's supervision. The dye (safranine) was used as a tool to measure the magnitude of the transmembrane gradient generated with liposomes. The dye's redistribution is easily detected by eye and correlates with>98% encapsulation of the dye. This observation became the basis from which remote drug loading methods developed. Remote loading methodology involves the addition of drugs to pre-formed liposomes with a transmembrane gradient, which results in drug redistribution to the liposome interior. Doxorubicin, as an example drug candidate, complexes manganese trapped within the liposome. A color change accompanied drug encapsulation as the solution went from an orange to purple. This manuscript reviews and adds a novel perspective on the use of metal complexation reactions to prepare PRCosomes. The technology described provides a versatile method to form metal-drug complexed within liposomes. The purpose of this work is to differentiation between drug candidate loading that is caused by metal-drug complexation and loading driven by formation of a pH gradient.
机译：作为Pieter R. Cullis的致敬，该手稿鉴定了脂质体制剂，其呈现他的缩写：巯基。观察到脂质体内的相当反应性复合物，而这份手稿的高级作者则完成了他的博士学位。论文下的监督。用作测量用脂质体产生的跨膜梯度的大小的工具。染料的再分分配通过眼睛很容易检测到，与染料的封装> 98％封装相关。这种观察结果成为开发的远程药物加载方法的基础。远程加载方法涉及将药物添加到具有跨膜梯度的预形成脂质体中，这导致药物再分布到脂质体内部。 Doxorubicin，作为一个例子药物候选物，复合物悬浮在脂质体内。颜色改变伴有药物封装，因为解决方案从橙色到紫色。本手稿评价和增加了使用金属络合反应以制备巯基的新颖性观点。所描述的技术提供了一种多功能的方法，可在脂质体内形成金属药物。本作作品的目的是在药物候选负载率之间的差异化，该候选负载是由金属药物络合和通过形成pH梯度驱动的负载而引起的。

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