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首页> 外文期刊>Journal of dermatological science >Keratinocytes as sensors and central players in the immune defense against Staphylococcus aureus in the skin
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Keratinocytes as sensors and central players in the immune defense against Staphylococcus aureus in the skin

机译：当皮肤葡萄球菌的免疫防御中的角质蛋白和中央球员

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摘要

Healthy human skin provides an effective mechanical as well as immunologic barrier against pathogenic microorganisms with keratinocytes as the main cell type in the epidermis actively participating and orchestrating the innate immune response of the skin. As constituent of the outermost layer encountering potential pathogens they have to sense signals from the environment and must be able to initiate a differential immune response to harmless commensals and harmful pathogens. Staphylococci are among the most abundant colonizers of the skin: Whereas Staphylococcus epidermidis is part of the skin microbiota and ubiquitously colonizes human skin, Staphylococcus aureus is only rarely found on healthy human skin, but frequently colonizes the skin of atopic dermatitis (AD) patients. This review highlights recent advances in understanding how keratinocytes as sessile innate immune cells orchestrate an effective defense against S. aureus in healthy skin and the mechanisms leading to an impaired keratinocyte function in AD patients. (C) 2017 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.
机译：健康的人体皮肤提供有效的机械和免疫屏障，免疫障碍与角质形成细胞作为表皮中的主要细胞类型积极参与和策划皮肤的先天免疫应答。作为遇到潜在病原体的最外层的组成部分，它们必须感测来自环境的信号，并且必须能够引发对无害的共生和有害病原体的差异免疫应答。葡萄球菌是皮肤上最丰富的殖民聚集体之一：葡萄球菌是皮肤微生物的一部分，并且普遍地殖民殖民，人体皮肤，金黄色葡萄球菌仅在健康的人体皮肤上仅发现，但经常殖民植入特应性皮炎（AD）患者的皮肤。本综述突出了了解畸形细胞如何如何在健康皮肤中衡量对牙龈的术语天生的免疫细胞如何进行术治疗，并在AD患者中产生有效的防御。 （c）2017年日本调查皮肤病学会。由elsevier爱尔兰有限公司出版。保留所有权利。

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