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首页> 外文期刊>Journal of cosmetic and laser therapy >5-aminolaevulinic acid-based photodynamic therapy induces both necrosis and apoptosis of keratinocytes in plantar warts
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5-aminolaevulinic acid-based photodynamic therapy induces both necrosis and apoptosis of keratinocytes in plantar warts

机译：基于5-氨基乙酰硫酸的光动力学治疗诱导跖疣中角质形成细胞的坏死和凋亡

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Background 5-aminolaevulinic acid (ALA)-based photodynamic therapy (ALA-PDT) is an effective treatment for proliferative skin diseases. Many studies revealed that ALA-PDT induces apoptosis of cancer cells. However, the mechanism of PDT in warts is not fully elucidated. Objective This study was designed to explore the efficacy of ALA-PDT for plantar warts and its possible mechanism. Methods Twenty-five patients with plantar warts underwent four rounds of ALA-PDT at weekly intervals. Therapeutic effects were observed 1 month since last treatment. The adverse reactions were also recorded during and after the procedure. To observe histological changes, 5 patients accepted tissue biopsies before and 24 h after first PDT treatment. Results Twenty-two patients (88%) showed a complete response. Twenty patients complained of a mild burning sensation during treatment, and four patients developed local edema immediately after red light exposure. Five patients had burns after treatment, which disappeared within 24 h. Histologically, epidermal keratinocytes demonstrated remarkable necrocytosis and apoptosis after PDT. Conclusions ALA-PDT is highly effective for treatment of plantar warts. The most common adverse effects observed in patients are pain and edema. ALA-PDT might eradicate plantar warts by activating both necrosis and apoptosis to trigger the death of proliferating keratinocytes.
机译：背景技术5-氨基氨基乙酸（ALA）基于光动力治疗（ALA-PDT）是对增殖性皮肤病的有效治疗方法。许多研究表明Ala-PDT诱导癌细胞的凋亡。然而，疣中PDT的机制尚未完全阐明。目的旨在探讨Ala-PDT为跖疣的功效及其可能的机制。方法以每周间隔进行25例Purtorar疣的患者进行四轮ALA-PDT。自上次治疗后1个月观察治疗效果。在程序期间和之后还记录了不良反应。为了观察组织学变化，5名患者在首次PDT处理后24小时接受组织活组织检查。结果二十二名患者（88％）表现出完整的反应。 20名患者在治疗过程中抱怨轻度灼热感，并在红灯暴露后立即开发出局部水肿。治疗后，五名患者烧伤，在24小时内消失。组织学上，表皮角蛋白细胞表现出显着的坏吞吐量和PDT后的细胞凋亡。结论Ala-PDT对跖疣的治疗非常有效。患者观察到的最常见的不良反应是疼痛和水肿。 Ala-PDT可以通过激活坏死和细胞凋亡来消除Purtorar疣，以引发增殖角质形成细胞的死亡。

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