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首页> 外文期刊>Biotechnology Progress >Hemorheological Implications of Perfluorocarbon Based Oxygen Carrier Interaction with Colloid Plasma Expanders and Blood
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Hemorheological Implications of Perfluorocarbon Based Oxygen Carrier Interaction with Colloid Plasma Expanders and Blood

机译：全氟碳基氧载体与胶体血浆扩张剂和血液相互作用的血液流变学意义

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摘要

Perfluorocarbon (PFC) emulsions used as artificial oxygen carriers lack colloid osmotic pressure (COP) and must be administered with colloid-based plasma expanders (PEs). Although PFC emulsions have been widely studied, there is limited information about PFC emulsion interaction with PEs and blood. Their interaction forms aggregates due to electrostatic and rheological phenomena, and change blood rheology and blood flow. This study analyzes the effects of the interaction between PFC emulsions with blood in the presence of clinically-used PEs. The rheological behavior of the mixtures was analyzed in vitro in parallel with in vivo analysis of blood flow in the microcirculation using intravital microscopy, when PEs were administered in a clinically relevant scenario. The interaction between the PFC emulsion and PE with blood produced PFC droplets and red blood cell (RBCs) aggregation and increased blood viscosity in a shear dependent fashion. The PFC droplets formed aggregates when mixed with PEs containing electrolytes, and the aggregation increased with the electrolyte concentration. Mixtures of PFC with PEs that produced PFC aggregates also induced RCBs aggregation when mixed with blood, increasing blood viscosity at low shear rates. The more viscous suspension at low shear rates produced a blunted blood flow velocity profile in vivo compared to nonaggregating mixtures of PFC and PEs. For the PEs evaluated, human serum albumin produced minimal to undetectable aggregation. PFC and PEs interaction with blood can affect sections of the microcirculation with low shear rates (e.g., arterioles, venules, and pulmonary circulation) when used in a clinical setting, because persistent aggregates could cause capillary occlusion, decreased perfusion, pulmonary emboli or focal ischemia.
机译：用作人造氧气载体的全氟化碳（PFC）乳液缺乏胶体渗透压（COP），必须与基于胶体的血浆膨胀剂（PEs）一起使用。尽管已经对PFC乳液进行了广泛的研究，但是关于PFC乳液与PE和血液相互作用的信息有限。由于静电和流变现象，它们的相互作用形成聚集体，并改变血液流变学和血流。这项研究分析了在临床上使用的PE的存在下PFC乳剂与血液之间相互作用的影响。当在临床相关的情况下使用PE时，在体外分析混合物的流变特性，同时使用活体显微镜对体内微循环中的血流进行分析。 PFC乳液和PE之间的相互作用与血液产生PFC液滴和红细胞（RBC）聚集，并以剪切依赖性方式增加血液粘度。 PFC液滴与含有电解质的PE混合时会形成聚集体，并且聚集体会随着电解质浓度的增加而增加。 PFC与生成PFC聚集体的PE的混合物在与血液混合时也会引起RCB聚集，从而在低剪切速率下增加血液粘度。与PFC和PE的非聚集混合物相比，在低剪切速率下粘度更高的悬浮液在体内产生钝化的血流速度曲线。对于所评估的PE，人血清白蛋白产生的凝集最少至无法检测到。在临床上使用时，PFC和PE与血液的相互作用会影响低剪切率的微循环部分（例如小动脉，小静脉和肺循环），因为持久的聚集体可能导致毛细血管闭塞，灌注减少，肺栓塞或局灶性缺血。

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