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首页> 外文期刊>Journal of Experimental Botany >Arabidopsis HEAT SHOCK TRANSCRIPTION FACTORA1b regulates multiple developmental genes under benign and stress conditions
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Arabidopsis HEAT SHOCK TRANSCRIPTION FACTORA1b regulates multiple developmental genes under benign and stress conditions

机译：拟南芥热休克转录因子1b在良性和压力条件下调节多种发育基因

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In Arabidopsis thaliana, HEAT SHOCK TRANSCRIPTION FACTORA1b (HSFA1b) controls resistance to environmental stress and is a determinant of reproductive fitness by influencing seed yield. To understand how HSFA1b achieves this, we surveyed its genome-wide targets (ChIP-seq) and its impact on the transcriptome (RNA-seq) under non-stress (NS), heat stress (HS) in the wild type, and in HSFA1b-overexpressing plants under NS. A total of 952 differentially expressed HSFA1b-targeted genes were identified, of which at least 85 are development associated and were bound predominantly under NS. A further 1780 genes were differentially expressed but not bound by HSFA1b, of which 281 were classified as having development-associated functions. These genes are indirectly regulated through a hierarchical network of 27 transcription factors (TFs). Furthermore, we identified 480 natural antisense non-coding RNA (cisNAT) genes bound by HSFA1b, defining a further mode of indirect regulation. Finally, HSFA1b-targeted genomic features not only harboured heat shock elements, but also MADS box, LEAFY, and G-Box promoter motifs. This revealed that HSFA1b is one of eight TFs that target a common group of stress defence and developmental genes. We propose that HSFA1b transduces environmental cues to many stress tolerance and developmental genes to allow plants to adjust their growth and development continually in a varying environment.
机译：在拟南芥中，热冲击转录因子1b（HSFA1b）控制对环境应激的抵抗力，是通过影响种子产量来控制生殖健康的决定因素。要了解HSFA1B如何实现这一点，我们如何调查其基因组目标（芯片-SEQ）及其对野生类型中的非应力（NS），热应激（HS）的转录组（RNA-SEQ）的影响，以及在NS下的HSFA1B过表达植物。鉴定了总共952种差异表达的HSFA1B靶向基因，其中至少85个是相关的显影，主要在NS下界定。另外的1780个基因差异表达但不受HSFA1B的结合，其中281分为具有发展相关的功能。这些基因间接调节通过27个转录因子（TFS）的分层网络调节。此外，我们鉴定了由HSFA1B结合的480个天然反义非编码RNA（CISNAT）基因，限定了进一步的间接调节模式。最后，HSFA1B针对性的基因组特征不仅患者患者，而且疯狂的盒子，绿叶和G盒启动子主题。这表明HSFA1B是占靶向常见的压力防御和发育基因的TFS之一。我们提出HSFA1B将环境提示转换为许多应激耐受性和发育基因，以便在不同的环境中不断地调节其生长和发展。

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