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Quorum sensing inhibitors: An overview

机译：群体感应抑制剂：概述

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摘要

Excessive and indiscriminate use of antibiotics to treat bacterial infections has lead to the emergence of multiple drug resistant strains. Most infectious diseases are caused by bacteria which proliferate within quorum sensing (QS) mediated biofilms. Efforts to disrupt biofilms have enabled the identification of bioactive molecules produced by prokaryotes and eukaryotes. These molecules act primarily by quenching the QS system. The phenomenon is also termed as quorum quenching (QQ). In addition, synthetic compounds have also been found to be effective in QQ. This review focuses primarily on natural and synthetic quorum sensing inhibitors (QSIs) with the potential for treating bacterial infections. It has been opined that the most versatile prokaryotes to produce QSI are likely to be those, which are generally regarded as safe. Among the eukaryotes, certain legumes and traditional medicinal plants are likely to act as QSIs. Such findings are likely to lead to efficient treatments with much lower doses of drugs especially antibiotics than required at present
机译：过度和不加选择地使用抗生素治疗细菌感染已导致多种耐药菌株的出现。大多数传染病是由细菌引起的，这些细菌在群体感应（QS）介导的生物膜中繁殖。破坏生物膜的努力使得能够鉴定出原核生物和真核生物产生的生物活性分子。这些分子主要通过淬灭QS系统起作用。此现象也称为法定猝灭（QQ）。此外，还发现合成化合物在QQ中有效。这篇综述主要侧重于具有治疗细菌感染潜力的天然和合成群体感应抑制剂（QSI）。认为生产QSI的最通用的原核生物可能是那些，通常被认为是安全的。在真核生物中，某些豆类和传统药用植物很可能充当QSI。这些发现可能导致比目前所需的药物（尤其是抗生素）剂量低得多的有效治疗

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