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首页> 外文期刊>Journal of feline medicine and surgery >Investigation of hallmarks of carbonyl stress and formation of end products in feline chronic kidney disease as markers of uraemic toxins
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Investigation of hallmarks of carbonyl stress and formation of end products in feline chronic kidney disease as markers of uraemic toxins

机译：碳基胁迫标志的标志和猫培养基肾病中末端产物的构建作为尿毒症毒素的标志物

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Objectives Cats are commonly affected by chronic kidney disease (CKD). Many reactive carbonyl intermediates and end products originating from the oxidative stress pathways are recognised as uraemic toxins and may play a role in CKD progression. The aim of the present study is to confirm whether carbonyl end-product formation is higher in cats affected by CKD and to assess whether an angiotensin-converting enzyme inhibitor (ACEi) might affect these hallmarks. Methods Twenty-two cats were divided into three groups: a control group (CG), cats with CKD and cats with CKD treated with an ACEi. Serum levels of pentosidine, carboxymethyllysine, advanced oxidation protein products, malondialdehyde, methylglyoxal and hexanoyl-lysine were measured. In addition, biochemical parameters and systolic blood pressure were evaluated. After checking for normality, comparisons between groups were performed followed by multiple comparison tests. P values = 0.05 were considered significant. Correlations between concentrations of the considered biomarkers and of the other metabolic parameters were investigated. Results Advanced oxidation protein products, malondialdehyde and hexanoyl-lysine concentrations were significantly higher in CKD and ACEi-treated groups compared with the CG (P 0.05). Carboxymethyllysine increased in the ACEi-treated group when compared with the CG, whereas intermediate values of these biomarkers were found in the CKD group (P 0.05). The ACEi-treated group showed the highest values of carboxymethyllysine, advanced oxidation protein products and hexanoyl-lysine. By contrast, the CKD group had the highest concentration of malondialdehyde. No statistically significant difference was found in the levels of pentosidine or methylglyoxal. End products correlated with creatinine and urea and with each other. Conclusions and relevance Significantly high concentrations of both intermediate and end products of carbonyl/oxidative stress were detected in CKD cats. This is the first study to have concurrently taken into account several uraemic toxins and biochemical parameters in cats affected by CKD.
机译：目标猫通常受慢性肾病（CKD）的影响。来自氧化应激途径的许多反应性羰基中间体和最终产品被认为是尿毒性毒素，并且可能在CKD进展中发挥作用。本研究的目的是确认受CKD影响的猫的碳基末端产物形成是否较高，并评估血管紧张素转换酶抑制剂（ACEI）可能影响这些标志。方法将二十二只猫分为三组：对照组（CG），猫用CKD和CKD用ACEI处理的猫。测定了血清水平的戊嘌呤，羧甲基氰基，晚期氧化蛋白质产品，丙二醛，甲基乙二醛和己酰基赖氨酸。此外，评估生化参数和收缩压。在检查正常性后，进行组之间的比较，然后进行多个比较测试。 P值＆ = 0.05被认为是显着的。研究了所考虑的生物标志物和其他代谢参数的浓度之间的相关性。结果与CG（P <0.05）相比，CKD和ACEI处理基团的高级氧化蛋白产物，丙二醛和己酰基赖氨酸浓度明显高于较高（P <0.05）。与CG相比，羧甲基氰基含量增加，而在CKD基团中发现这些生物标志物的中间值（P <0.05）。 Acei治疗组显示羧甲基氰基，晚期氧化蛋白质产品和己酰基赖氨酸的最高值。相比之下，CKD组浓度最高的丙二醛。在戊胺或甲基乙二醛的水平中发现了没有统计学意义的差异。最终产品与肌酐和尿素相关，彼此相关。结论和相关性在CKD猫中检测到羰基/氧化胁迫的中间和最终产物的显着高浓度。这是第一项研究，同时考虑受CKD影响的猫中的几种尿毒症毒素和生物化学参数。

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