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Methionine production by fermentation.

机译:通过发酵生产蛋氨酸。

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摘要

Fermentation processes have been developed for producing most of the essential amino acids. Methionine is one exception. Although microbial production of methionine has been attempted, no commercial bioproduction exists. Here, we discuss the prospects of producing methionine by fermentation. A detailed account is given of methionine biosynthesis and its regulation in some potential producer microorganisms. Problems associated with isolation of methionine overproducing strains are discussed. Approaches to selecting microorganism having relaxed and complex regulatory control mechanisms for methionine biosynthesis are examined. The importance of fermentation media composition and culture conditions for methionine production is assessed and methods for recovering methionine from fermentation broth are considered.
机译:已经开发出用于生产大多数必需氨基酸的发酵方法。蛋氨酸是一个例外。尽管已尝试微生物生产蛋氨酸,但不存在商业生物生产。在这里,我们讨论了通过发酵生产蛋氨酸的前景。详细介绍了蛋氨酸的生物合成及其在某些潜在生产者微生物中的调控。讨论了与蛋氨酸高产菌株分离有关的问题。检验了选择具有蛋氨酸生物合成松弛和复杂调节控制机制的微生物的方法。评估了发酵培养基组成和培养条件对蛋氨酸生产的重要性,并考虑了从发酵液中回收蛋氨酸的方法。

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