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首页> 外文期刊>Digestive diseases >Single Nucleotide Polymorphisms in MicroRNA-Binding Site of Epidermal Growth Factor Receptor Signaling Pathway and Susceptibility to Esophageal Squamous Cell Carcinoma
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Single Nucleotide Polymorphisms in MicroRNA-Binding Site of Epidermal Growth Factor Receptor Signaling Pathway and Susceptibility to Esophageal Squamous Cell Carcinoma

机译：表皮生长因子受体信号传导途径微小荷纳结合位点的单核苷酸多态性，对食管鳞状细胞癌的敏感性

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Background: Epidermal growth factor receptor (EGFR) signaling pathway plays a fundamental role in regulating cell proliferation, differentiation, apoptosis, migration, and so on, which are associated with tumor development, including the esophageal squamous cell carcinoma (ESCC). The single nucleotide polymorphisms (SNPs) of microRNA-binding sites with target genes in the EGFR pathway could lead to alteration in the combination of microRNA with target genes and contribute to the susceptibility of cancer. Methods: A case-control study including 494 ESCC patients and 494 controls was carried out to investigate the genetic susceptibility of 4 microRNA-binding site SNPs (rs712 in the binding site of KRAS to let-7, rs8904 in the binding site of NFBIA to mir-507, rs3738894 in the binding site of protein kinase C epsilon to mir-218, rs701848 in the binding site of phosphatase and tensin to mir-1304) as well as the interactions of gene-environment in the development of ESCC. Results: The results showed that compared with CC genotype, the individuals with TT and TT + CT genotypes of rs701848 were significantly associated with increased ESCC risk (OR adjusted 1.56, 95% CI 1.07-2.27 and 1.41, 1.01-1.97). The gene-Environment interaction between rs3738894 and smoking history was associated with the risk of esophageal cancer. Conclusions: Results of these analyses underline the support of the notion that SNPs in microRNA-binding site of EGFR signaling pathway play certain important roles in the susceptibility to ESCC.
机译：背景技术表皮生长因子受体（EGFR）信号通路在调节细胞增殖，分化，凋亡，迁移等方面发挥着基本作用，如肿瘤发育，包括食道鳞状细胞癌（ESCC）。 MicroRNA结合位点与EGFR途径中靶基因的单核苷酸多态性（SNP）可能导致MicroRNA与靶基因的组合改变，有助于癌症的易感性。方法：案例对照研究，包括494名ESCC患者和494例对照，以研究4 microRNA结合位点SNP的遗传易感性（KRA的结合位点，在NFBIA的结合位点中的KRAS的结合位点。 MiR-507，RS3738894在蛋白激酶C epsilon的结合位点至miR-218，磷酸酶结合位点的MiR-218，Rs701848至miR-1304）以及基因环境在ESCC发育中的相互作用。结果：结果表明，与CC基因型相比，RS701848的TT和TT + CT基因型的个体与增加的ESCC风险显着相关（或调整1.56,95％CI 1.07-2.27和1.41,1.01-1.97）。 RS3738894与吸烟史之间的基因环境相互作用与食管癌的风险有关。结论：这些分析的结果强调了EGFR信号通知途径MicroRNA结合位点中SNP的概念在对ESCC的易感性中发挥着某些重要作用。

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