...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Inorganic Biochemistry: An Interdisciplinary Journal >Synergistic antibacterial mechanism of Bi2Te3 nanoparticles combined with the ineffective beta-lactam antibiotic cefotaxime against methicillin-resistant Staphylococcus aureus
【24h】

Synergistic antibacterial mechanism of Bi2Te3 nanoparticles combined with the ineffective beta-lactam antibiotic cefotaxime against methicillin-resistant Staphylococcus aureus

机译：Bi2Te3纳米粒子的协同抗菌机理与无效β-内酰胺抗生素CEFotaxime联合甲氧西林抗性金黄色葡萄球菌

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Methicillin-resistant Staphylococcus aureus (MRSA) infections have become a serious threat to public health because traditional antibiotics are less efficient. Here, we developed a simple and efficient combination of Bi2Te3 nanoparticles (NPs) with beta-lactam antibiotics cefotaxime (CTX), which presented significant synergistic antibacterial activity against MRSA. The minimal inhibitory concentration of CTX decreased from 256 to 32 mu g/mL in the presence of 8 mu g/mL Bi2Te3 NPs. The results of cell membrane potential and cellular K+ content measurements demonstrated that the destruction of membrane functions is a factor in the synergistic mechanism. Furthermore, the induction of cellular reactive oxygen species generation, inhibition of beta-lactamases induced by CTX and direct damage to the cell structure constituted other factors of the synergistic mechanism. These observations suggest that reviving the efficacy of ineffective fi-lactam antibiotic CTX by Bi2Te3 NPs may be a potentially effective therapeutic strategy to overcome refractory MRSA infections.
机译：耐甲氧西林金黄色葡萄球菌（MRSA）感染已成为对公共卫生的严重威胁，因为传统的抗生素效率较低。在这里，我们用β-内酰胺抗生素Cefotaxime（CTX）开发了Bi2te3纳米颗粒（NPS）的简单有效组合，其对MRSA具有显着的协同抗菌活性。 CTX的最小抑制浓度在8μg/ ml Bi2Te 3 NPS存在下从256〜32μg/ ml降低。细胞膜电位和细胞k +含量测量的结果表明，膜功能的破坏是协同机制的一个因素。此外，细胞反应性氧物种产生，抑制CTX诱导的β-内酰胺酶和对细胞结构的直接损伤的抑制构成了协同机制的其他因素。这些观察结果表明，恢复无效的Fi-lactam抗生素CTX对Bi2Te3 NPS的疗效可能是克服难治性MRSA感染的潜在有效的治疗策略。

著录项

  • 来源
  • 作者

    Liu Xiangyu; Ma Lulu; Chen Fan; Liu Junzi; Yang Hao; Lu Zhong;

  • 作者单位

    Wuhan Inst Technol Res Ctr Environm Ecol &

    Engn Sch Environm Ecol &

    Biol Engn 206 Guanggu First Rd Wuhan 430073 Hubei Peoples R China;

    Wuhan Inst Technol Res Ctr Environm Ecol &

    Engn Sch Environm Ecol &

    Biol Engn 206 Guanggu First Rd Wuhan 430073 Hubei Peoples R China;

    Wuhan Inst Technol Res Ctr Environm Ecol &

    Engn Sch Environm Ecol &

    Biol Engn 206 Guanggu First Rd Wuhan 430073 Hubei Peoples R China;

    Wuhan Inst Technol Res Ctr Environm Ecol &

    Engn Sch Environm Ecol &

    Biol Engn 206 Guanggu First Rd Wuhan 430073 Hubei Peoples R China;

    Wuhan Inst Technol Res Ctr Environm Ecol &

    Engn Sch Environm Ecol &

    Biol Engn 206 Guanggu First Rd Wuhan 430073 Hubei Peoples R China;

    Wuhan Inst Technol Res Ctr Environm Ecol &

    Engn Sch Environm Ecol &

    Biol Engn 206 Guanggu First Rd Wuhan 430073 Hubei Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

    Bi2Te3 nanoparticles; Cefotaxirne; Methicillin-resistant Staphylococcus aureus; Synergistic antibacterial effect; Mechanism;

    机译：Bi2te3纳米颗粒;Cefotaxirne;耐甲氧西林金黄色葡萄球菌;协同抗菌效果;机制;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号