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首页> 外文期刊>Journal of industrial and engineering chemistry >A core-shell polymeric-inorganic hybrid nanocomposite system for MRI-visible gene delivery application in cancer immunotherapy
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A core-shell polymeric-inorganic hybrid nanocomposite system for MRI-visible gene delivery application in cancer immunotherapy

机译：用于癌症免疫疗法的MRI可见基因递送应用的核 - 壳聚合物 - 无机杂交纳米复合体系

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摘要

Due to the tumor immune escape mechanism, strategies like the utilization of bispecific antibodies were used to assist immunotherapy. Herein a visible polymer-inorganic hybrid gene vehicle had been prepared to deliver anti-EpCAM/anti-CD3 encoding minicircle DNA into normal cells thus these transfected cells effectively secreted bispecific antibody with bioactivity. In the experiments, this compound system exhibited excellent biocompatibility, high transfection efficiency and ultrasensitive imaging capacity. Furthermore, the transfected cells could be detected under the MR imaging system and the gene product showed an outstanding immune effect. In conclusion, this nanocomposite showed synergistic advantages in gene delivery and non-invasive MR imaging. (C) 2019 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
机译：由于肿瘤免疫逃逸机制，使用了双特异性抗体的利用的策略来提供免疫疗法。 在此，已制备可见聚合物 - 无机杂交基因载体以将抗EPCAM /抗CD3递送将小型核心DNA编码成正常细胞，因此这些转染的细胞有效地分泌了具有生物活性的双特异性抗体。 在实验中，该化合物系统表现出优异的生物相容性，高转染效率和超敏成像能力。 此外，可以在MR成像系统下检测转染的细胞，并且基因产物显示出突出的免疫效果。 总之，该纳米复合材料在基因递送和非侵入性MR成像中表现出协同的优势。 （c）2019年韩国工程化学学会。 elsevier b.v出版。保留所有权利。

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  • 作者

    Cai Jiali; Chen Guochuang; Jin Rongrong; Deng Changhui; Huang Shihui; Yuan Xuexia; Chen Gengjia; Zhao Jing; Wang Zhiyong; Ai Hua;

  • 作者单位

    Sun Yat Sen Univ Sch Mat Sci &

    Engn Ctr Funct Biomat Key Lab Polymer Composite &

    Funct Mat Minist Educ Guangzhou 510275 Guangdong Peoples R China;

    Chinese Acad Sci Shenzhen Inst Adv Technol Lab Gene &

    Cell Engn Shenzhen 518055 Peoples R China;

    Sichuan Univ Natl Engn Res Ctr Biomat Chengdu 610064 Sichuan Peoples R China;

    Sun Yat Sen Univ Sch Mat Sci &

    Engn Ctr Funct Biomat Key Lab Polymer Composite &

    Funct Mat Minist Educ Guangzhou 510275 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Mat Sci &

    Engn Ctr Funct Biomat Key Lab Polymer Composite &

    Funct Mat Minist Educ Guangzhou 510275 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Mat Sci &

    Engn Ctr Funct Biomat Key Lab Polymer Composite &

    Funct Mat Minist Educ Guangzhou 510275 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Mat Sci &

    Engn Ctr Funct Biomat Key Lab Polymer Composite &

    Funct Mat Minist Educ Guangzhou 510275 Guangdong Peoples R China;

    Chinese Acad Sci Shenzhen Inst Adv Technol Lab Gene &

    Cell Engn Shenzhen 518055 Peoples R China;

    Sun Yat Sen Univ Sch Mat Sci &

    Engn Ctr Funct Biomat Key Lab Polymer Composite &

    Funct Mat Minist Educ Guangzhou 510275 Guangdong Peoples R China;

    Sichuan Univ Natl Engn Res Ctr Biomat Chengdu 610064 Sichuan Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学工业;
  • 关键词

    Bispecific antibody; Cancer immunotherapy; Gene transfection; Magnetic resonance imaging; Superparamagnetic iron oxide;

    机译：双特异性抗体;癌症免疫疗法;基因转染;磁共振成像;超顺磁性氧化铁;

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