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首页> 外文期刊>Journal of industrial and engineering chemistry >Coating of an antimicrobial peptide on solid substrate via initiated chemical vapor deposition
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Coating of an antimicrobial peptide on solid substrate via initiated chemical vapor deposition

机译:通过启动化学气相沉积在固体基材上涂覆抗微生物肽

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摘要

We developed a simple and efficient method for the immobilization of a potent AMP (SHAP1) on the surface of solid supports via initiated chemical vapor deposition (iCVD). The surface of the slide glass was functionalized with vinyl-containing polymer by iCVD, and Cys-linked SHAP1 peptides could be immobilized on the functionalized surface (glass and latex glove) via simple thiol-ene click chemistry with high efficiency. The antimicrobial efficacy of the immobilized peptides was investigated against two typical pathogenic bacteria - Escherichia coli and Staphylococcus aureus - and it was revealed that SHAP1-GS-Cys exhibited high antibacterial efficacy (96%). (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
机译:我们通过发起的化学气相沉积(ICVD)开发了一种简单而有效的方法,用于固定在固体支撑件表面上的有效放大器(Shap1)。 通过ICVD用含乙烯基聚合物官能化的滑动玻璃的表面,并且通过简单的硫醇-NE键单击官能化表面(玻璃和乳胶手套)可以固定在官能化表面(玻璃和胶乳手套)上的粘合剂。 针对两种典型的致病细菌和金黄色葡萄球菌研究了固定化肽的抗菌效果 - 揭示了Shap1-GS-Cys表现出高抗菌效力(& 96%)。 (c)2017年韩国工程和工程化学学会。 elsevier b.v出版。保留所有权利。

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  • 作者单位

    Korea Adv Inst Sci &

    Technol Plus Program BK21 Dept Chem &

    Biomol Engn 291 Daehak Ro Daejeon 34141 South Korea;

    Korea Adv Inst Sci &

    Technol Plus Program BK21 Dept Chem &

    Biomol Engn 291 Daehak Ro Daejeon 34141 South Korea;

    Korea Adv Inst Sci &

    Technol Plus Program BK21 Dept Chem &

    Biomol Engn 291 Daehak Ro Daejeon 34141 South Korea;

    KRIBB Synthet Biol &

    Bioengn Res Ctr 125 Gwahak Ro Daejeon 34141 South Korea;

    Korea Adv Inst Sci &

    Technol Dept Biol Sci 291 Daehak Ro Daejeon 34141 South Korea;

    Korea Adv Inst Sci &

    Technol Plus Program BK21 Dept Chem &

    Biomol Engn 291 Daehak Ro Daejeon 34141 South Korea;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学工业;
  • 关键词

    Antimicrobial peptide; iCVD; Coating; Latex glove;

    机译:抗微生物肽;ICVD;涂层;乳胶手套;

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