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首页> 外文期刊>Biotechnology Progress >A Novel Electrospinning Target to Improve the Yield of Uniaxially Aligned Fibers
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A Novel Electrospinning Target to Improve the Yield of Uniaxially Aligned Fibers

机译：一种新型的静电纺丝靶，可提高单轴排列纤维的产量

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摘要

Electrospinning is a useful technique that can generate micro and nanometer-sized fibers. Modification of the electrospinning parameters,such as deposition target geometry,can generate uniaxially aligned fibers for use in diverse applications ranging from tissue engineering to material fabrication. For example,meshes of fibers have been shown to mimic the extracellular matrix networks for use in smooth muscle cell proliferation. Further,aligned fibers can guide neurites to grow along the direction of the fibers. Here we present a novel electrospinning deposition target that combines the benefits of two previously reported electrodes: the standard parallel electrodes and the spinning wheel with a sharpened edge. This new target design significantly improves aligned fiber yield. Specifically,the target consists of two parallel aluminum plates with sharpened edges containing a bifurcating angle of 26°. Electric field computations show a larger probable area of aligned electric field vectors. This new deposition target allows fibers to deposit on a larger cross-sectional area relative to the existing parallel electrode and at least doubles the yield of uniaxially aligned fibers. Further,fiber alignment and morphology are preserved after collection from the deposition target.
机译：电纺丝是可以产生微米和纳米尺寸的纤维的有用技术。修改电纺丝参数（例如沉积目标的几何形状）可以生成单轴对齐的纤维，以用于从组织工程到材料制造的各种应用中。例如，已经显示出纤维网模拟了用于平滑肌细胞增殖的细胞外基质网络。此外，对齐的纤维可以引导神经突沿着纤维的方向生长。在这里，我们介绍了一种新颖的静电纺丝沉积靶材，该靶材结合了两个先前报道的电极的优势：标准的平行电极和带有锋利边缘的纺车。这种新的靶材设计显着提高了对齐纤维的产量。具体来说，目标由两个平行的铝板组成，这些铝板的锐利边缘的分叉角为26°。电场计算显示对齐的电场矢量的可能区域更大。这种新的沉积靶材可使纤维相对于现有的平行电极沉积在更大的横截面上，并使单轴排列的纤维的产量至少翻倍。此外，从沉积靶收集后，纤维排列和形态得以保留。

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