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首页> 外文期刊>World Mycotoxin Journal >Monascus spp. used in wheat kernel solid-state fermentations: growth, extrolite production and citrinin cytotoxicity
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Monascus spp. used in wheat kernel solid-state fermentations: growth, extrolite production and citrinin cytotoxicity

机译：蒙斯马斯SPP。 用于小麦核固态发酵：生长，结块生产和柠檬水细胞毒性

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摘要

Monascus fermentation products can be consumed as food or feed supplements or used as food colouring or flavouring agents. In this study, qPCR and Q-TOF LC/MS methods were developed to monitor Monascus ruber and Monascus purpureus growth and extrolite (lovastatin, mevastatin, as well as the regulated mycotoxin, citrinin (CIT)) production, respectively. Wheat kernels were inoculated with one strain of each species during a solid-state fermentation followed over 63 days. Different growth and extrolite production patterns were clearly observed for the 2 tested strains. After 63 days, high lovastatin levels (up to 0.5 mg/g) were reached for M. ruber wheat fermented kernels while M. purpureus only yielded 0.1 mg/g of lovastatin at best, suggesting that M ruber may be a better candidate for lovastatin production in a wheat-based model. Mevastatin levels were low and stable for both species. However, M. ruber fermented wheat kernels also contained the highest CIT content, up to 4.2 mu g/g, i.e. at levels above the regulation threshold set by the European Union. CIT toxicity was then determined in vitro on bovine kidney cells, showing an IC10 of 6.10(-4) M. At maximum concentrations encountered during solid-state fermentation, CIT toxicity was very low under chronic exposure.
机译：普通话发酵产品可作为食品或饲料补充剂食用或用作食用色素或调味剂。在该研究中，开发了QPCR和Q-TOF LC / MS方法，以监测MonascusRuber和Monascus Purpureus生长和阉割（Lovastatin，Mevastatin，以及受调节的霉菌毒素，柠檬水（CIT））生产。在固态发酵过程中，在固态发酵过程中接种一株菌株，在63天内接种每个物种的一个菌株。对于2个测试的菌株，清楚地观察到不同的生长和结块生产模式。在63天后，达到高洛伐他汀水平（高达0.5mg / g）的M.Ruber小麦发酵核，而M. purpureus最多只产生0.1mg / g的洛伐他汀，表明M Ruber可能是洛伐他汀的更好候选者生产在基于小麦的模型中。兆孢素水平较低，两种物种稳定。然而，M.Ruber发酵小麦核也含有最高的CIT含量，高达4.2μg/ g，即在欧洲联盟设定的调节门槛高于调节阈值的水平。然后在牛肾细胞上体外测定Cit毒性，显示在固态发酵期间遇到的最大浓度为6.10（-4）M的IC10，在慢性暴露下CIT毒性非常低。

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  • 来源
    《World Mycotoxin Journal》 |2019年第3期|共10页
  • 作者

    Coton M.; Hymery N.; Piqueras J.; Poirier E.; Mounier J.; Coton E.; Picot A.;

  • 作者单位

    Univ Brest Lab Univ Biodiversite &

    Ecol Microbienne F-29280 Plouzane France;

    Univ Brest Lab Univ Biodiversite &

    Ecol Microbienne F-29280 Plouzane France;

    Univ Brest Lab Univ Biodiversite &

    Ecol Microbienne F-29280 Plouzane France;

    Univ Brest Lab Univ Biodiversite &

    Ecol Microbienne F-29280 Plouzane France;

    Univ Brest Lab Univ Biodiversite &

    Ecol Microbienne F-29280 Plouzane France;

    Univ Brest Lab Univ Biodiversite &

    Ecol Microbienne F-29280 Plouzane France;

    Univ Brest Lab Univ Biodiversite &

    Ecol Microbienne F-29280 Plouzane France;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 微生物学;
  • 关键词

    solid-state fermentation; pigments; citrinin; Monascaceae;

    机译：固态发酵;颜料;番茄素;蒙斯奇西亚;

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