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首页> 外文期刊>Biotechnology Progress >Optimization of Ultrasound-Accelerated Synthesis of Enzymatic Octyl Hydroxyphenylpropionate by Response Surface Methodology
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Optimization of Ultrasound-Accelerated Synthesis of Enzymatic Octyl Hydroxyphenylpropionate by Response Surface Methodology

机译：响应面法优化超声加速酶催化羟苯丙酸辛酯的合成

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摘要

The ultrasound-accelerated enzymatic synthesis of octyl hydroxyphenylpropionate (OHPP) from p-hydroxyphenylpropionic acid (HPPA) and octanol was investigated in this study. A commercially available immobilized lipase from Candida antarctica, Novozym 435, was used as the biocatalyst. A three-level-three-factor Box-Behnken design experiment and response surface methodology were used to evaluate the effects of temperature, reaction time, and enzyme activity on percent yield of OHPP. The results indicated that temperature and enzyme activity significantly affected percent yield, whereas reaction time did not. A model for the synthesis of OHPP was established. Based on a ridge max analysis, the optimum conditions for OHPP synthesis were predicted to use a reaction temperature of 58.8° C, a reaction time of 14.6 h, and an enzyme activity of 410.5 PLU with a yield of 98.5%. A reaction was performed under these optimal conditions, and a yield of 97.5% ± 0.1% was obtained.
机译：本研究研究了由对羟基苯丙酸（HPPA）和辛醇超声加速酶促合成羟基苯丙酸辛酯（OHPP）。来自南极假丝酵母的市售固定化脂肪酶Novozym 435用作生物催化剂。使用三级三因素Box-Behnken设计实验和响应面方法评估温度，反应时间和酶活性对OHPP收率的影响。结果表明温度和酶活性显着影响百分产率，而反应时间则不。建立了合成OHPP的模型。基于脊最大分析，预测用于OHPP合成的最佳条件是使用反应温度为58.8℃，反应时间为14.6h，酶活性为410.5PLU，收率为98.5％。在这些最佳条件下进行反应，产率为97.5％±0.1％。

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