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首页> 外文期刊>Journal of inverse and ill-posed problems >A numerical algorithm for constructing an individual mathematical model of HIV dynamics at cellular level
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A numerical algorithm for constructing an individual mathematical model of HIV dynamics at cellular level

机译:一种在蜂窝水平下构建艾滋病毒动力学单独数学模型的数值算法

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摘要

In this paper a problem of specifying HIV-infection parameters and immune response using additional measurements of the concentrations of the T-lymphocytes, the free virus and the immune effectors at fixed times for a mathematical model of HIV dynamics is investigated numerically. The problem of the parameter specifying of the mathematical model (an inverse problem) is reduced to a problem of minimizing an objective function describing the deviation of the simulation results from the experimental data. A genetic algorithm for solving the least squares function minimization problem is implemented and investigated. The results of a numerical solution of the inverse problem are analyzed.
机译:在本文中,在数值上研究了使用额外的T淋巴细胞,自由病毒和免疫效应的额外测量来指定HIV感染参数和免疫应答的问题。 将数学模型(逆问题)的参数指定的参数的问题减少到最小化描述模拟结果来自实验数据的偏差的问题。 实现和研究了解决最小二乘函数最小化问题的遗传算法。 分析了逆问题的数值解的结果。

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