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首页> 外文期刊>Journal of mass spectrometry: JMS >Vibrating tip spray ionization mass spectrometry for direct sample analysis
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Vibrating tip spray ionization mass spectrometry for direct sample analysis

机译：振动尖端喷射电离质谱进行直接样品分析

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摘要

In this work, a vibrating tip spray ionization source was developed for direct mass spectrometric analysis of raw samples under voltage-free condition. A solid tip was mounted on a vibrator, and the solid tip was placed on the front of MS inlet. Liquid, viscous, and bulk solid samples could be directly loaded on the tip-end surface, and then a drop of solvent at microliter level was subsequently loaded on the tip for dissolution and extraction of analytes, and a vibrator was then started to atomize and ionize the analytes under ambient condition. We demonstrated vibrating tip spray mass spectrometry in various applications, including food safety, pharmaceutical analysis, and forensic science. Furthermore, in situ analysis of biological tissues and in vivo analysis of living plants were conveniently performed, due to voltage-free. Different vibration frequencies and solvent compositions were investigated. The analytical performances, including sensitivity, reproducibility, and linear range, were investigated. The ionization process and mechanism were also discussed in this work.
机译：在这项工作中，开发了一种振动尖端喷射电离源，用于在无电压条件下直接质谱分析原料样品。将固体尖端安装在振动器上，将固体尖端放置在MS入口的前部。液体，粘性和批量固体样品可以直接装载在尖端表面上，然后在尖端上装载微透镜水平下的溶剂滴，以溶解和提取分析物，然后开始振动器雾化在环境条件下电离分析物。我们在各种应用中展示了振动尖端喷射质谱，包括食品安全，药物分析和法医学。此外，由于无电压，在对生物组织的原位分析和对生物植物的体内分析。研究了不同的振动频率和溶剂组合物。研究了分析性能，包括灵敏度，再现性和线性范围。在这项工作中还讨论了电离过程和机制。

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  • 来源
    《Journal of mass spectrometry: JMS》 |2019年第9期|共8页
  • 作者

    Yao Ya-Nan; Wu Lin; Di Dandan; Yuan Zi-Cheng; Hu Bin;

  • 作者单位

    Jinan Univ Inst Mass Spectrometry &

    Atmospher Environm Guangdong Prov Engn Res Ctr Online Source Apporti Guangzhou 510632 Guangdong Peoples R China;

    Jinan Univ Inst Mass Spectrometry &

    Atmospher Environm Guangdong Prov Engn Res Ctr Online Source Apporti Guangzhou 510632 Guangdong Peoples R China;

    Jinan Univ Inst Mass Spectrometry &

    Atmospher Environm Guangdong Prov Engn Res Ctr Online Source Apporti Guangzhou 510632 Guangdong Peoples R China;

    Jinan Univ Inst Mass Spectrometry &

    Atmospher Environm Guangdong Prov Engn Res Ctr Online Source Apporti Guangzhou 510632 Guangdong Peoples R China;

    Jinan Univ Inst Mass Spectrometry &

    Atmospher Environm Guangdong Prov Engn Res Ctr Online Source Apporti Guangzhou 510632 Guangdong Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分析化学;
  • 关键词

    direct sample analysis; food safety; forensic science; in vivo analysis; pharmaceutical analysis; vibrating tip spray ionization;

    机译：直接样本分析;食品安全;法医学;体内分析;药物分析;振动尖端喷雾电离;

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