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首页> 外文期刊>Journal of mass spectrometry: JMS >How to avoid interfering electrochemical reactions in ESI-MS analysis
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How to avoid interfering electrochemical reactions in ESI-MS analysis

机译：如何避免干扰ESI-MS分析中的电化学反应

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摘要

The presence of electrochemical reactions occurring in an electrospray processes at the point where the current enters the liquid is discussed since the early 1990's. This current transfer to the liquid results in oxidation or reduction of either electrolyte species in the liquid sprayed or of the electrode material in contact with the liquid. As a result, new chemical species are generated. These products of the electrochemical reaction might be detected as altered species in mass spectra; they might be volatile and not recognized at all or accumulate on the electrode surface and cause cross contamination later on. In other cases, it might happen that the products of the electrochemical reactions are the only detectable species formed from an otherwise nondetectable analyte. An electrospray setup in which electrochemical reactions do not interfere with the analyte under investigation excludes the electrochemical reaction as source of sample contamination and sample altering and may serve as reference setup for experiments focused on the electrochemical reaction itself. We present a simple and inexpensive current coupling approach and specify operation conditions for which any impact of the electrochemical reaction on the sample under investigation is inherently excluded. On the basis of a practical example, we show the impact of the electrochemical reaction on sample composition and demonstrate the benefit of using the proposed current coupling method. Because of the obvious benefit of this method and its simple realization, it has the potential to be employed as standard feeding approach, especially for electrosprays operated at small flow rates.
机译：自20世纪90年代初以来，在电流进入液体的点处存在电化学反应的存在。该电流转移到液体中，导致液体中喷涂或与液体接触的电极材料中的电解质物种的氧化或减少。结果，产生了新的化学物质。这些电化学反应的产品可以在质谱中被检测为改变的物种;它们可能是挥发性的，并且在电极表面上全部或积聚并不能识别，并在后面引起交叉污染。在其他情况下，电化学反应的产物可能是由其他不可识别的分析物形成的唯一可检测物种。电化喷雾器设置，其中电化学反应不会干扰正在进行的分析物中，作为样品污染的源和样品改变的电化学反应不包括电化学反应，并且可以作为专注于电化学反应本身的实验的参考设置。我们介绍了一种简单且廉价的电流耦合方法，并指定了在调查中对样品上的电化学反应对电化学反应的任何影响的操作条件。在实际的例子的基础上，我们展示了电化学反应对样品组成的影响，并证明了使用所提出的电流偶联方法的益处。由于这种方法的明显益处及其简单的实现，它具有用作标准喂养方法的可能性，特别是对于以小流速操作的电喷雾器。

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