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首页> 外文期刊>Journal of mass spectrometry: JMS >Analysis of the chemical components of Qixianqingming granules and their metabolites in rats by UPLC-ESI-Q-TOF-MS
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Analysis of the chemical components of Qixianqingming granules and their metabolites in rats by UPLC-ESI-Q-TOF-MS

机译：UPLC-ESI-Q-TOF-MS大鼠赤仙清明颗粒化学成分及其代谢物分析

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摘要

Qixianqingming granules (QXQM) comprise a traditional Chinese medicine (TCM) formula that was developed based on the combination of TCM theory and clinical practice. This formula has been proven to effectively treat asthma. In this study, an analytical procedure using ultraperformance liquid chromatography, coupled with electrospray ionization quadrupole time-of-flight mass spectrometry, was established for the rapid separation and sensitive identification of the chemical components in QXQM and its metabolites in serum of rats. Seventy-two compounds were systematically identified in QXQM, including flavonoids, terpenoids, anthraquinones, phenylethanoid glycosides, stilbenes, alkaloids, and organic acids. Thirteen prototype compounds and 29 metabolites were detected in the serum of rats. The results provided fundamental information for further studying the mechanisms and clinical application of QXQM.
机译：祁县清明颗粒（QXQM）包括一种基于中医理论和临床实践的组合开发的中药（TCM）配方。 已被证明该公式可有效治疗哮喘。 在本研究中，使用超细液相色谱法与电喷雾电离四极杆飞行时间质谱法的分析方法建立了QXQM中化学成分及其在大鼠血清中的化学成分的快速分离和敏感的鉴定。 在QXQM中系统地鉴定了七十二种化合物，包括类黄酮，萜类化合物，蒽醌，苯乙醇糖苷，斯蒂芬，生物碱和有机酸。 在大鼠血清中检测到13种原型化合物和29种代谢物。 结果提供了进一步研究QXQM的机制和临床应用的基本信息。

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