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首页> 外文期刊>Journal of Medical Entomology >The Octopamine Receptor Is a Possible Target for Eugenol-Induced Hyperactivity in the Blood-Sucking Bug Triatoma infestans (Hemiptera: Reduviidae)
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The Octopamine Receptor Is a Possible Target for Eugenol-Induced Hyperactivity in the Blood-Sucking Bug Triatoma infestans (Hemiptera: Reduviidae)

机译：八达醇受体是植物吸血虫子瘤患有丁烯醇诱导的多动的可能靶标（Hemiptera：Reduviidae）

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摘要

Eugenol is a major component of the essential oils in cloves and other aromatic plants. In insects, it produces toxic effects and repellency, and there is evidence that its site of action is the octopamine receptor. The objective of the present study was to explore whether the octopamine receptor is involved in the hyperactivity produced by eugenol in the blood-sucking bug Triatoma infestans (Klug). This insect is the main vector of Chagas disease in Latin America. Four treatments were topically applied on third instar nymphs: 1) octopamine, 2) eugenol, 3) phentolamine hydrochloride (an antagonist of the octopamine receptor) followed by octopamine, and 4) phentolamine hydrochloride followed by eugenol. Both octopamine and eugenol hyperactivated the nymphs. However, pretreatment with phentolamine hydrochloride inhibited the hyperactivating effect of both compounds. These results are in agreement with previous works on Drosophila melanogaster (Meigen) (Diptera: Drosophilidae) and the American cockroach. They suggest that the octopamine receptor is a possible site of action for eugenol.
机译：丁香酚是丁香和其他芳香植物的精油的主要成分。在昆虫中，它产生毒性效应和排斥性，有证据表明其动作现场是八甘醇受体。本研究的目的是探讨八甘醇的受体是否参与了丁烯醇在血液吸血虫Triatoma infestans（Klug）中产生的多动。这种昆虫是拉丁美洲芝麻病的主要载体。四种治疗局部施用在第三龄若虫：1）辛辣醇，2）丁香醇，3）盐酸芬胺（八大戊胺受体的拮抗剂），然后是辛辣甘油，盐酸芬胺，然后是丁香酚。八丁胺和丁烯醇都过度激活了若虫。然而，用盐酸浮胺的预处理抑制了两种化合物的多动作用。这些结果与之前的果蝇（梅根）（Diptera：Drosophilidae）和美国蟑螂的作品一致。他们表明八胺受体是丁醇的可能的作用位点。

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