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首页> 外文期刊>Journal of Medical Virology >Prognosis and predictors of hepatocellular carcinoma in elderly patients infected with hepatitis B virus
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Prognosis and predictors of hepatocellular carcinoma in elderly patients infected with hepatitis B virus

机译：乙型肝炎病毒感染的老年患者肝细胞癌的预后和预测因子

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With rapidly aging population in the world, many elderly patients present with hepatitis B virus (HBV) infection. We conducted a retrospective cohort study involving 359 untreated HBV patients aged 60 and older who were free of hepatocellular carcinoma (HCC) and acute hepatitis at the initial visit, and examined the incidence of HCC and liver-related mortality rate. During the follow-up period of 7.9 years (range, 0-25 years), 26 patients (7.2% of patients) developed HCC, 20 patients died from liver-related diseases (61% of total deaths), including HCC, liver failure, and gastrointestinal bleeding. The cumulative rates of HCC at years 5, 10, and 15 were 6.5%, 15.6%, and 15.6%, respectively. The cumulative rates of mortality from liver-related diseases at years 5, 10, 15 were 3.3%, 12.3%, and 15.7%, respectively. Multivariate analysis identified HBV DNA (>= 5.0 Log IU/mL), male gender, and FIB4-Index (>= 3.6) as significant independent risk factors for HCC, and alpha-fetoprotein (>= 10 ng/mL) as significant independent predictors of liver-related mortality. We conclude that high levels of HBV DNA, progression of liver fibrosis, and male gender are independent risk factors of HCC in untreated patients infected with HBV aged 60 and older.
机译：随着世界上迅速衰老的，许多老年患者患有乙型肝炎病毒（HBV）感染。我们进行了回顾性队列研究，涉及60岁及以上的未经治疗的HBV患者，初步访问中没有肝细胞癌（HCC）和急性肝炎，并检查了HCC和肝脏相关死亡率的发生率。在7.9岁的后续期间（0-25岁的范围），26名患者（7.2％的患者）发育了HCC，20名患者从肝脏有关的疾病（占总死亡人数的61％），包括HCC，肝脏衰竭和胃肠道出血。第500,10和15年HCC的累积率分别为6.5％，15.6％和15.6％。肝脏相关疾病的累积率分别为3.3％，12.3％和15.7％。多变量分析确定了HBV DNA（> = 5.0 log Iu / ml），男性性别和Fib4-Index（> = 3.6）作为HCC的重要危险因素，以及α-胎儿（> = 10 ng / ml），如同重要的独立肝脏相关死亡率的预测因素。我们得出结论，高水平的HBV DNA，肝纤维化进展，以及男性性别是未处理患者的HCC的独立危险因素，感染60岁及以上的HBV。

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