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首页> 外文期刊>Journal of Medical Virology >Cytomegalovirus infection and atherosclerosis risk: A meta-analysis
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Cytomegalovirus infection and atherosclerosis risk: A meta-analysis

机译：巨细胞病毒感染和动脉粥样硬化风险：META分析

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Human cytomegalovirus (HCMV) infection is an important risk factor for atherosclerosis (AS). Numerous studies have been conducted to analyze the association between HCMV infection and risk of AS, but no clear consensus has been reached. So the objective of this paper was aimed to demonstrate the relationship between HCMV and AS by doing a meta-analysis. Relative literature was searched through the electronic databases PubMed, Embase, and CNKI. Data were accurately assessed and analyzed independently by two investigators. Ultimately, the 30 studies, involving 3328 cases and 2090 controls were included in our meta-analysis. The positive ratio of HCMV IgG, IgM, DNA and pp65 were, respectively, 63.26% (923/1459), 25.46% (69/271), 33.69% (381/1131), and 50.32% (158/314) in case patients. Meanwhile the positive ratio of HCMV IgG, IgM, DNA, and pp65 were, respectively, 52.12% (541/1038), 1.55% (3/194), 13.72% (79/576), and 12.26% (28/229) in control subjects. The positive ratio of HCMV infection was higher in atherosclerosis group than that in non-atherosclerosis group. Especially in Asian group, calculated odds ratios for the presence of HCMV infection in IgG-based HCMV tests, IgM-based tests, PCR-based tests, and pp65-based tests, expressed as OR (95% confidence intervals, 95%CI), were 3.07(95%CI 2.09-4.51), 8.92(95%CI 3.17-25.11), 6.75 (95%CI 3.50-13.02), and 5.72(95%CI 1.51-21.58), respectively. The meta-analysis results showed that HCMV infection is significant connected with an increased risk for AS.
机译：人巨细胞病毒（HCMV）感染是动脉粥样硬化（AS）的重要危险因素。已经进行了许多研究，分析了HCMV感染与风险之间的关联，但没有明确共识。因此，本文的目的旨在展示HCMV与荟萃分析之间的关系。通过电子数据库被搜索，Embase和CNKI搜查了相对文献。通过两位调查人员独立评估和分析数据。最终，在我们的META分析中包含30项研究，涉及3328例和2090例对照。分别为63.26％（923/1459），25.46％（69/271），33.69％（381/1131）和50.32％（158/314）的阳性比例。耐心。同时，HCMV IgG，IgM，DNA和PP65的正比例分别为52.12％（541/1038），1.55％（3/194），13.72％（79/576）和12.26％（28/229）在对照科目中。动脉粥样硬化组的HCMV感染的阳性比在非动脉粥样硬化组中较高。特别是在亚洲组中，计算基于IgG的HCMV试验中HCMV感染，基于IgM的测试，基于PCR基测试和PP65的试验的计算的差距比，表达或（95％置信区间，95％CI） ，分别为3.07（95％CI 2.09-4.51），8.92（95％CI 3.17-25.11），6.75（95％CI 3.50-13.02）和5.72（95％CI 1.51-21.58）。荟萃分析结果表明，HCMV感染与增加的风险有显着相关。

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