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Magnetic Force Microscopy of Iron Oxide Nanoparticles and Their Cellular Uptake

机译:氧化铁纳米粒子的磁力显微镜及其细胞摄取

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Magnetic force microscopy has the capability to detect magnetic domains from a close distance,which can provide the magnetic force gradient image of the scanned samples and also simultaneously obtain atomic force microscope (AFM) topography image as well as AFM phase image. In this work,we demonstrate the use of magnetic force microscopy together with AFM topography and phase imaging for the characterization of magnetic iron oxide nanoparticles and their cellular uptake behavior with the MCF7 carcinoma breast epithelial cells. This method can provide useful information such as the magnetic responses of nanoparticles,nanoparticle spatial localization,cell morphology,and cell surface domains at the same time for better understanding magnetic nanoparticle-cell interaction. It would help to design magnetic-related new imaging,diagnostic and therapeutic methods.
机译:磁力显微镜具有从近距离检测磁畴的能力,可以提供扫描样本的磁力梯度图像,并同时获得原子力显微镜(AFM)形貌图像和AFM相图像。在这项工作中,我们证明了磁力显微镜与AFM形貌和相成像的结合用于表征磁性氧化铁纳米颗粒及其对MCF7癌乳腺上皮细胞的细胞摄取行为。该方法可以提供有用的信息,例如纳米粒子的磁响应,纳米粒子的空间定位,细胞形态和细胞表面域,同时可以更好地了解磁性纳米粒子与细胞的相互作用。这将有助于设计与磁性有关的新成像,诊断和治疗方法。

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