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首页> 外文期刊>Biotechnology Progress >A Rotating Bed System Bioreactor Enables Cultivation of Primary Osteoblasts on Well-Characterized Sponceram? Regarding Structural and Flow Properties
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A Rotating Bed System Bioreactor Enables Cultivation of Primary Osteoblasts on Well-Characterized Sponceram? Regarding Structural and Flow Properties

机译：旋转床系统生物反应器能够在特性良好的海绵上培养原代成骨细胞？关于结构和流动特性

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摘要

The development of bone tissue engineering depends on the availability of suitable bioma-terials, a well-defined and controlled bioreactor system, and on the use of adequate cells. The biomaterial must fulfill chemical, biological, and mechanical requirements. Besides bio-compatibility, the structural and flow characteristics of the biomaterial are of utmost importance for a successful dynamic cultivation of osteoblasts, since fluid percolation within the microstructure must be assured to supply to cells nutrients and waste removal. Therefore, the biomaterial must consist of a three-dimensional structure, exhibit high porosity and present an interconnected porous network. Sponceram , a ZrO2 based porous ceramic, is characterized in the presented work with regard to its microstructural design. Intrinsic permeability is obtained through a standard Darcy's experiment, while Young's modulus is derived from a two plates stress-strain test in the linear range. Furthermore, the material is applied for the dynamic cultivation of primary osteoblasts in a newly developed rotating bed bioreactor.
机译：骨组织工程学的发展取决于合适的生物材料的可用性，定义明确和受控的生物反应器系统以及适当细胞的使用。生物材料必须满足化学，生物学和机械要求。除了具有生物相容性外，生物材料的结构和流动特性对于成功动态培养成骨细胞至关重要，因为必须确保微结构内的流体渗透能为细胞提供营养和废物清除。因此，生物材料必须由三维结构组成，具有高孔隙率并具有相互连接的多孔网络。 Sponceram是一种基于ZrO2的多孔陶瓷，其微观结构设计在本工作中得到了表征。本征渗透率是通过标准达西实验获得的，而杨氏模量则是从线性范围内的两块板的应力应变试验得出的。此外，该材料还用于在新开发的旋转床生物反应器中动态培养原代成骨细胞。

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