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首页> 外文期刊>Journal of Materials Chemistry, B. materials for biology and medicine >A graphene-polyurethane composite hydrogel as a potential bioink for 3D bioprinting and differentiation of neural stem cells
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A graphene-polyurethane composite hydrogel as a potential bioink for 3D bioprinting and differentiation of neural stem cells

机译：石墨烯 - 聚氨酯复合水凝胶作为用于3D生物监测和神经干细胞的分化的潜在生物链

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3D bioprinting is known as an additive manufacturing technology that builds customized structures from cells and supporting biocompatible materials for the repair of damaged tissues or organs. In this study, we prepared water-dispersible graphene and graphene oxide, which are 2D nanomaterials with high conductivity and potential applications in neural tissue engineering. Moreover, we synthesized a new biodegradable waterborne polyurethane with soft segments that mostly contained poly(epsilon-caprolactone) (2 kDa) and 20 mol% of shorter (1.5 kDa) poly(D, L-lactide) chains. This polyurethane dispersion at a solid content of 25% in a cell culture medium underwent a sol-gel transition near human body temperature with a suitable gel modulus. After this, we mixed graphene or graphene oxide with polyurethane to prepare a graphene-based nanocomposite hydrogel for neural stem cell (NSC) printing. The rheological properties of the graphene-based nanocomposite hydrogel were suitable for the printing and survival of NSCs. Furthermore, the addition of a very low content (25 ppm) of graphene nanomaterials to the hydrogel significantly enhanced the oxygen metabolism (2- to 4-fold increase) as well as the neural differentiation of NSCs. In summary, the graphene-polyurethane nanocomposite hydrogel may be a possible bioink for printing 3D cell-laden tissue constructs for neural tissue engineering.
机译：3D BioPlinting被称为添加剂制造技术，可从细胞构建定制结构并支持用于修复受损组织或器官的生物相容性材料。在这项研究中，我们制备了水分散性石墨烯和石墨烯，其是具有高导电性和神经组织工程中的潜在应用的2D纳米材料。此外，我们合成了一种新的可生物降解的水性聚氨酯，具有多大含量的软链段，主要含有聚（ε-己内酯）（2kDa）和20摩尔％的较短（1.5kDa）聚（D，L-丙交酯）链。在细胞培养基中固体含量为25％的聚氨酯分散体在人体温附近的溶胶 - 凝胶转变用合适的凝胶模量进行。此后，我们用聚氨酯混合石墨烯或石墨烯氧化物以制备用于神经干细胞（NSC）印刷的石墨烯类纳米复合水凝胶。基于石墨烯的纳米复合水凝胶的流变性能适用于NSC的印刷和存活。此外，向水凝胶中添加非常低的石墨烯纳米物质（25ppm），显着增强了氧代谢（2至4倍）以及NSC的神经分化。总之，石墨烯 - 聚氨酯纳米复合水凝胶可以是用于印刷用于神经组织工程的3D细胞包装组织构建体的可能的生物链。

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