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首页> 外文期刊>Journal of Materials Chemistry, B. materials for biology and medicine >A dual-responsive, hyaluronic acid targeted drug delivery system based on hollow mesoporous silica nanoparticles for cancer therapy
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A dual-responsive, hyaluronic acid targeted drug delivery system based on hollow mesoporous silica nanoparticles for cancer therapy

机译：基于中空介孔二氧化硅纳米粒子的双响应，透明质酸靶向药物输送系统癌症治疗

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摘要

In this study, a novel drug delivery system (HMSNs-SS-HA) based on hollow mesoporous silica nanoparticles (HMSNs) was developed for delivering anticancer drugs (e.g., doxorubicin (DOX)) to targeted tumour cells by using disulfide bonds as redox-sensitive linkers and hyaluronic acid (HA) molecules as both capping and targeting agents. Well-dispersed HMSNs were synthesized with a dimension of around 100 nm. Detailed physical characterization further demonstrated that HMSNs-SS-HA has been successfully constructed. The in vitro drug release experiments displayed the enzyme and redox dual-responsive and sustained drug release properties of DOX loaded HMSNs-SS-HA. Additionally, a series of biological evaluations indicated that these DOX loaded HMSNs-SS-HA could accurately target murine mammary carcinoma (4T1) cells to induce cell apoptosis in vitro and suppress tumour growth in vivo. These results demonstrated that DOX loaded HMSNs-SS-HA was suitable as a potential and efficient drug delivery nanosystem for cancer therapy.
机译：在该研究中，基于中空介孔二氧化硅纳米粒子（HMSNS-SS-HA）进行了一种新的药物递送系统（HMSNS-SS-HA），通过使用二硫键作为氧化还原来递送抗癌药物（例如，多柔比星（DOX））至靶向肿瘤细胞。敏感的接头和透明质酸（HA）分子作为封端和靶向剂。分散良好的HMSNS合成，尺寸约为100nm。详细的物理表征进一步证明了HMSNS-SS-HA已成功构建。体外药物释放实验显示酶和氧化还原双响应性和持续的DOX载荷的HMSNS-SS-HA药物释放性能。另外，一系列生物学评估表明，这些DOX负载的HMSNS-SS-HA可以准确地靶向小鼠乳腺癌（4T1）细胞，以诱导体外细胞凋亡并抑制体内肿瘤生长。这些结果表明，DOX负载HMSNS-SS-HA适合作为癌症治疗的潜在和有效的药物递送纳米系统。

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    Huang Lin; Liu Jia; Gao Fan; Cheng Qian; Lu Bo; Zheng Hua; Xu Haixing; Xu Peihu; Zhang Xianzheng; Zeng Xuan;

  • 作者单位

    Wuhan Univ Technol Sch Chem Chem Engn &

    Life Sci Wuhan 430070 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Union Hosp Tongji Med Coll Res Ctr Tissue Engn &

    Regenerat Med Wuhan 430022 Hubei Peoples R China;

    Wuhan Univ Key Lab Biomed Polymers Minist Educ Wuhan 430072 Hubei Peoples R China;

    Wuhan Univ Key Lab Biomed Polymers Minist Educ Wuhan 430072 Hubei Peoples R China;

    Wuhan Univ Technol Sch Chem Chem Engn &

    Life Sci Wuhan 430070 Hubei Peoples R China;

    Wuhan Univ Technol Sch Chem Chem Engn &

    Life Sci Wuhan 430070 Hubei Peoples R China;

    Wuhan Univ Technol Sch Chem Chem Engn &

    Life Sci Wuhan 430070 Hubei Peoples R China;

    Wuhan Univ Technol Sch Chem Chem Engn &

    Life Sci Wuhan 430070 Hubei Peoples R China;

    Wuhan Univ Key Lab Biomed Polymers Minist Educ Wuhan 430072 Hubei Peoples R China;

    Wuhan Univ Key Lab Biomed Polymers Minist Educ Wuhan 430072 Hubei Peoples R China;

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  • 正文语种 eng
  • 中图分类 分析化学;
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