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首页> 外文期刊>Biotechnology Progress >Separation, Antitumor Activities, and Encapsulation of Polypeptide from Chlorella pyrenoidosa
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Separation, Antitumor Activities, and Encapsulation of Polypeptide from Chlorella pyrenoidosa

机译：小球藻小球藻多肽的分离，抗肿瘤活性及其包封

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摘要

Chlorella pyrenoidosa is a unicellular green algae and has been a popular foodstuff worldwide. However, no reports on the antitumor peptides from such a microalgae are available in the literature. In this study, using low-temperature high-pressure extraction, enzymatic hydrolysis, ion exchange, and gel filtration chromatography, we separated a polypeptide that exhibited inhibitory activity on human liver cancer HepG2 cells, and named the polypeptide CPAP (C. pyrenoidosa antitumor polypeptide). Furthermore, the micro- and nanoencapsulation of CPAP were investigated by using two methods: complex coacervation and ionotropic gelation. The in vitro release tests revealed that CPAP was well preserved against gastric enzymatic degradation after microanoencapsulation and the slowly controlled release in the intestine could be potentially achieved. These results suggest that CPAP may be a useful ingredient in food, nutraceutical, and pharmaceutical applications.
机译：绿藻（Chlorella pyrenoidosa）是一种单细胞绿藻，已成为世界范围内流行的食品。然而，在文献中没有关于这种微藻的抗肿瘤肽的报道。在这项研究中，我们使用低温高压萃取，酶水解，离子交换和凝胶过滤色谱法，分离了一种对人肝癌HepG2细胞具有抑制活性的多肽，并将其命名为CPAP（C. pyrenoidosa抗肿瘤多肽）。此外，通过两种方法研究了CPAP的微囊化和纳米囊化：复合凝聚和离子胶凝。体外释放测试表明，微/纳米囊封后，CPAP可以很好地保存以防胃酶降解，并且有可能在肠道中缓慢控制释放。这些结果表明，CPAP在食品，营养保健品和药物应用中可能是有用的成分。

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