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首页> 外文期刊>Journal of neurotrauma >Music Therapy Enhances Executive Functions and Prefrontal Structural Neuroplasticity after Traumatic Brain Injury: Evidence from a Randomized Controlled Trial
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Music Therapy Enhances Executive Functions and Prefrontal Structural Neuroplasticity after Traumatic Brain Injury: Evidence from a Randomized Controlled Trial

机译：音乐疗法增强了创伤性脑损伤后的执行功能和前额叶结构神经塑性：来自随机对照试验的证据

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Traumatic brain injury (TBI) causes lifelong cognitive deficits, particularly impairments of executive functioning (EF). Musical training and music-based rehabilitation have been shown to enhance cognitive functioning and neuroplasticity, but the potential rehabilitative effects of music in TBI are still largely unknown. The aim of the present crossover randomized controlled trial (RCT) was to determine the clinical efficacy of music therapy on cognitive functioning in TBI and to explore its neural basis. Using an AB/BA design, 40 patients with moderate or severe TBI were randomized to receive a 3-month neurological music therapy intervention either during the first (AB, n = 20) or second (BA, n = 20) half of a 6-month follow-up period. Neuropsychological and motor testing and magnetic resonance imaging (MRI) were performed at baseline and at the 3-month and 6-month stage. Thirty-nine subjects who participated in baseline measurement were included in an intention-to-treat analysis using multiple imputation. Results showed that general EF (as indicated by the Frontal Assessment Battery [FAB]) and set shifting improved more in the AB group than in the BA group over the first 3-month period and the effect on general EF was maintained in the 6-month follow-up. Voxel-based morphometry (VBM) analysis of the structural MRI data indicated that gray matter volume (GMV) in the right inferior frontal gyrus (IFG) increased significantly in both groups during the intervention versus control period, which also correlated with cognitive improvement in set shifting. These findings suggest that neurological music therapy enhances EF and induces fine-grained neuroanatomical changes in prefrontal areas.
机译：创伤性脑损伤（TBI）导致终身认知缺陷，特别是执行功能的损害（EF）。已经显示音乐训练和基于音乐的康复，以提高认知功能和神经塑性，但TBI音乐的潜在康复影响仍然很大程度上是未知的。目前交叉随机对照试验（RCT）的目的是确定音乐疗法对TBI中的认知功能的临床疗效，并探索其神经网络。使用AB / BA设计，40例中度或严重TBI的患者随机地接受3个月的神经系统音乐治疗干预，既是六（AB，N = 20）或第二（BA，N = 20）的一半） -Month跟进期。神经心理学和电机测试和磁共振成像（MRI）在基线和3个月和6个月阶段进行。参与基线测量的三十九个受试者包括多种归纳的意图分析。结果表明，一般EF（如前期评估电池[Fab]所示）并在AB组中设置换档，而不是在前3个月内的BA集团，并在6-月随访。结构MRI数据的voxel的形态学（VBM）分析表明，在干预与控制期间，两组右下额相回值（IFG）中的灰质体积（GMV）显着增加，这也与集合的认知改进相关转移。这些发现表明神经学音乐疗法增强了EF，并在前额叶区域诱导细粒度的神经杀菌变化。

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