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首页> 外文期刊>Journal of neuroendocrinology >Oxytocin levels in saliva correlate better than plasma levels with concentrations in the cerebrospinal fluid of patients in neurocritical care
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Oxytocin levels in saliva correlate better than plasma levels with concentrations in the cerebrospinal fluid of patients in neurocritical care

机译：唾液中的催产素水平优于血浆水平，在神经关注的患者的脑脊液中浓度优于血浆水平

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In the converging fields of neuroendocrinology and behavioural neuroscience, the interaction between peripheral secretion and the central release of oxytocin in humans has not yet been comprehensively assessed. Because the human brain is not directly accessible and the collection of human cerebrospinal fluid (CSF) usually requires invasive procedures, easier accessible compartments such as blood or saliva have attracted increasing attention. In the present study, we prospectively determined oxytocin concentrations in the 3 compartments comprising the plasma, CSF and saliva of 50 critically ill patients with neurological and neurosurgical diseases. All samples per patient were collected concomitantly. Oxytocin was measured by a highly sensitive and specific radioimmunoassay. The strength of correlation was assessed by the Spearman rank correlation coefficient. Correlation analyses revealed modest to strong correlations for oxytocin between the saliva and CSF compartments, whereas predominantly weak correlations were found between the CSF and plasma, as well as between the plasma and saliva compartments. In conclusion, we have demonstrated modest to strong correlations between the saliva and CSF compartments suggesting that saliva oxytocin may help to assess CSF oxytocin levels. By contrast, plasma oxytocin failed to correspond well with CSF oxytocin levels because predominantly weak correlations were found between the CSF and plasma, as well as between the plasma and saliva compartments, which are unlikely to have any biological relevance. Further research is needed to clarify to what extent saliva oxytocin may serve as a biomarker reflecting brain oxytocin activity.
机译：在神经内部内分泌和行为神经科学的聚合领域，尚未全面评估外周分泌和催产素的中央释放之间的相互作用。因为人脑不可接近，人脑脊髓液（CSF）的收集通常需要侵入性程序，所以更容易获得血液​​或唾液的可接近的隔室引起了越来越关注。在本研究中，我们在3个室中预先确定了催产素浓度，其包含血浆，CSF和50例神经外科疾病患者的血浆，CSF和唾液。每个患者的所有样品都被统一地收集。通过高敏感和特异性放射免疫测量测量催产素。通过Spearman等级相关系数评估相关强度。相关分析显示唾液和CSF隔室之间催产素的强相关性，而CSF和血浆在血浆和唾液隔室之间存在主要相关性弱相关性。总之，我们已经表现出唾液和CSF隔室之间的强烈相关性，表明唾液催产素可能有助于评估CSF催产素水平。相比之下，血浆催产素未能与CSF催产素水平相对应良好，因为CSF和血浆之间的主要相关性，以及等离子体和唾液室之间存在，这不太可能具有任何生物相关性。需要进一步的研究来澄清唾液催产素的程度可以作为反映脑催产素活性的生物标志物。

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