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首页> 外文期刊>Journal of neuroimaging >Cerebral White Matter Maturation Patterns in Preterm Infants: An MRI T2 Relaxation Anisotropy and Diffusion Tensor Imaging Study
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Cerebral White Matter Maturation Patterns in Preterm Infants: An MRI T2 Relaxation Anisotropy and Diffusion Tensor Imaging Study

机译：早产儿的脑白质成熟模式：MRI T2松弛各向异性和扩散张量成像研究

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ABSTRACT BACKGROUND AND PURPOSE Preterm birth is associated with worse neurodevelopmental outcome, but brain maturation in preterm infants is poorly characterized with standard methods. We evaluated white matter (WM) of infant brains at term‐equivalent age, as a function of gestational age at birth, using multimodal magnetic resonance imaging (MRI). METHODS Infants born very preterm (32 weeks gestation) and late preterm (33‐36 weeks gestation) were scanned at 3 T at term‐equivalent age using diffusion tensor imaging (DTI) and T2 relaxometry. MRI data were analyzed using tract‐based spatial statistics, and anisotropy of T2 relaxation was also determined. Principal component analysis and linear discriminant analysis were applied to seek the variables best distinguishing very preterm and late preterm groups. RESULTS Across widespread regions of WM, T2 is longer in very preterm infants than in late preterm ones. These effects are more prevalent in regions of WM that myelinate earlier and faster. Similar effects are obtained from DTI, showing that fractional anisotropy (FA) is lower and radial diffusivity higher in the very preterm group, with a bias toward earlier myelinating regions. Discriminant analysis shows high sensitivity and specificity of combined?T2 relaxometry and DTI for the detection of a distinct WM development pathway in very preterm infants. T2 relaxation is anisotropic, depending on the angle between WM fiber and magnetic field, and this effect is modulated by FA. CONCLUSIONS Combined T2 relaxometry and DTI characterizes specific patterns of retarded WM maturation, at term equivalent age, in infants born very preterm relative to late preterm.
机译：摘要背景和目的早产与较差的神经开发结果有关，但早产儿的脑成熟具有标准方法的特征性差。我们评估了使用多模式磁共振成像（MRI）作为出生时妊娠期的妊娠期患者的白质（WM）。方法使用扩散张量成像（DTI）和T2弛豫测量，在3T期间扫描婴幼儿（＆ 32周妊娠）和晚期早产（33-36周妊娠）。使用基于传道的空间统计分析MRI数据，并确定T2松弛的各向异性。应用主成分分析和线性判别分析来寻求最佳区分的变量，最早的早产和晚期预料。结果跨越WM的广泛区域，T2比晚期早产更长。这些效果在WM的区域中更为普遍，介于介于百分比和更快的情况下。从DTI获得了类似的效果，表明分数各向异性（FA）在非常预先介质的基团中较低，径向扩散率较高，并且偏向于早期的髓鞘区域。判别分析显示了合并的组合的高灵敏度和特异性，用于检测非常早产儿的不同WM发育途径的DTI。 T2松弛是各向异性的，具体取决于WM光纤和磁场之间的角度，并且通过FA调制该效果。结论组合T2弛豫和DTI在婴儿出生于晚期早产的婴儿出生时，在相同年龄的狭窄WM成熟的具体模式表征。

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