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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >MIF-173G/C polymorphism is associated with NMO disease severity
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MIF-173G/C polymorphism is associated with NMO disease severity

机译：MIF-173G / C多态性与NMO疾病严重相关

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摘要

Our knowledge about genetic factors that drive the worsening of neuromyelitis optica (NMO) is limited. Herein, we analyzed the macrophage migration inhibitory factor (MIF) -173G/C functional polymorphism in NMO patients and controls. Our data reveal that the frequency of the high-expression MIF genotypes (CC/GC) did not differ between the two groups. However, frequency of this genotypes was elevated in patients diagnosed with both optic neuritis and myelitis compared with patients that were diagnosed with only one symptom. Furthermore, patients carrying the CC/CG genotypes had significantly higher disability score. We conclude that MIF is associated with NMO severity rather than susceptibility.
机译：我们有关推动神经髓炎Optica（NMO）恶化的遗传因素的了解是有限的。 在此，我们分析了NMO患者和对照中的巨噬细胞迁移抑制因子（MIF）-173g / c官能多态性。 我们的数据表明，两组之间的高表达MIF基因型（CC / GC）的频率没有差异。 然而，与仅诊断出一种症状的患者诊断出患有视神经炎和脊髓型脊髓炎的患者，这种基因型的频率升高。 此外，携带CC / CG基因型的患者具有明显更高的残疾分数。 我们得出结论，MIF与NMO严重程度相关，而不是易感性。

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