...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Effect of carbamylated erythropoietin on major histocompatibility complex expression and neural differentiation of human neural stem cells.
【24h】

Effect of carbamylated erythropoietin on major histocompatibility complex expression and neural differentiation of human neural stem cells.

机译：氨基甲酰化促红细胞生成素对人神经干细胞主要组织相容性复杂表达和神经分化的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The expression of major histocompatibility complex (MHC) on human neural stem cells (hNSCs) is tightly related to the fate of these cells in transplantation, therefore strategies to relieve rejection and promote graft survival are necessary to be applied. This study investigated the effect of carbamylated erythropoietin (CEPO) on MHC expression and differentiation of hNSCs with or without IFN-gamma incubation. Results showed that low levels of MHC molecules were expressed on hNSCs and increased by IFN-gamma. CEPO enhanced MHC-I antigens in both proliferative and differentiated hNSCs, but decreased MHC-II antigens in differentiated hNSCs and those cells exposed to IFN-gamma. Furthermore, CEPO promoted neural differentiation of hNSCs and outgrowth of neurites. Western blot analysis revealed activation of Stat3, Stat5 and Akt during these processes. These results suggest that CEPO may have immunoregulatory function in hNSCs besides its neuroprotection.
机译：在人神经干细胞（HNSCs）上的主要组织相容性复合物（MHC）的表达与移植中这些细胞的命运紧密相关，因此需要应用缓解排斥和促进移植物存活的策略。 本研究研究了氨基甲酰化促红细胞生成素（CEPO）对MHC表达和分化HNSCs的影响，具有或不具有IFN-GAMMA孵育。 结果表明，低水平的MHC分子在HNSC上表达并通过IFN-γ增加。 CEPO增强了增殖和分化的HNSC中的MHC-I抗原，但在分化的HNSC中降低了MHC-II抗原，并且将这些细胞暴露于IFN-γ。 此外，CEPO促进了HNSCs的神经分化和神经遗株的产物。 Western印迹分析显示了这些过程中STAT3，Stat5和AKT的激活。 这些结果表明，除了其神经保护外，CEPO可以在HNSC中具有免疫调节功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号