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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Core-shell PLA-PVA porous microparticles as carriers for bacteriocin nisin
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Core-shell PLA-PVA porous microparticles as carriers for bacteriocin nisin

机译：核心壳PLA-PVA多孔微粒作为菌株乳链菌素的载体

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This work is focused on preparation of novel porous type of core-shell-structured microparticles based on polylactide (shell) and poly(vinyl alcohol) cross-linked with glutaric acid (GA) (core) prepared by water-in-oil-in-water solvent evaporation technique. The microparticle systems were used as delivery systems for immobilisation of model antibacterial agent - nisin. The effect of cross-linking and the initial amount of nisin on their morphology was investigated using scanning electron microscopy, BET analysis, zeta potential measurement and Fourier transform infra-red spectroscopy. Encapsulation efficiency and release profile of nisin from the microparticles were studied by high performance liquid chromatography. Antibacterial activity of the prepared systems was tested by dilution and spread plate technique. Results showed the microparticles in the size range of 9-16 mu m in diameter with spherical multi-hollow core-shell structure. The presence of cross-linking agent GA influences the release profile of the peptide and has synergistic effect on Listeria monocytogenes growth reduction.
机译：这项工作专注于制备基于聚丙酯（壳）和与通过水含油制备的戊二酸（Ga）（核心）交联的聚酰胺（壳）和聚（乙烯醇）的新型多孔型核 - 壳结构微粒 - 水溶剂蒸发技术。将微粒系统用作用于固定模型抗菌剂的递送系统 - Nisin。通过扫描电子显微镜，BET分析，Zeta电位测量和傅里叶变换红外光谱研究了交联和初始乳腺初始量对其形态的初始效果。通过高效液相色谱法研究了从微粒中的Nisin的封装效率和释放曲线。通过稀释和涂抹板技术测试制备的系统的抗菌活性。结果显示微粒的尺寸范围为9-16μm，直径为球形多空心芯壳结构。交联剂GA的存在会影响肽的释放曲线，对李斯特菌单核细胞增生的生长减少具有协同作用。

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