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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Assessment of formulated amodiaquine microparticles in Leishmania donovani infected rats
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Assessment of formulated amodiaquine microparticles in Leishmania donovani infected rats

机译：对莱山诺维多尼感染大鼠进行制备的氨基喹微粒的评估

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摘要

The aim of this study was to formulate, characterise and evaluate the activity of amodiaquine microparticles against Leishmania donovani. Microparticles were formulated by encapsulating the drug in bovine serum albumin using the spray-dryer method. The microparticles were evaluated for size, zeta potential, drug content, encapsulation efficiency and in vitro release profile. The size range of the microparticles formulated was between 1.9 and 10 mu m with an average zeta potential of -25.5 mV. Of the expected 20% drug loading, an average of 18.27% was obtained giving an encapsulation efficiency of 91.35%. Pharmacokinetic profile of amodiaquine improved with microencapsulation of the drug with C-max, AUC(048) and t(1//2) all significantly higher than amodiaquine solution. Amodiaquine microparticles showed an overall higher bioavailability and hence were more effective in eliminating intra-tissue parasites than the drug solution. It would therefore be expected that the formulated microparticles will be more effective in treating visceral leishmaniasis.
机译：本研究的目的是制定，表征和评估对抗Leishmania Donovani的氨基喹微粒的活性。通过使用喷雾干燥方法将药物包封在牛血清白蛋白中的微粒配制。评价微粒的尺寸，Zeta电位，药物含量，包封效率和体外释放曲线。配制的微粒的尺寸范围为1.9至10μm，平均Zeta电位为-25.5 mV。预期的20％药物载荷，平均获得18.27％，其封装效率为91.35％。具有C-MAX，AUC（048）和T（1 // 2）的药物微胶囊化的药代动力学谱改善，均明显高于Amodiaquine溶液。氨基喹微粒显示出总体上较高的生物利用度，因此在消除组织内寄生虫比药物溶液更有效。因此，预期在治疗内脏LeishManiaisis方面将更有效地进行配制的微粒。

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