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首页> 外文期刊>American journal of clinical dermatology >Deoxycholic Acid: A Review in Submental Fat Contouring
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Deoxycholic Acid: A Review in Submental Fat Contouring

机译：脱氧胆酸：膜下脂肪轮廓的回顾。

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Deoxycholic acid is a secondary bile acid involved in dietary fat emulsification/solubilization that causes adipocyte lysis when injected into subcutaneous fat tissue. A 10 mg/mL injectable solution of synthetic deoxycholic acid (Kybella (TM); Belkyra (TM)) is indicated in various countries, including the USA and several within Europe/the EU, to improve the appearance of moderate to severe convexity or fullness associated with submental fat (SMF) in adults, where it is currently the only approved treatment for fat below the chin. In several phase III trials conducted in this setting, injecting deoxycholic acid 2 mg/cm(2) into the SMF reduced the convexity/fullness of moderate to severe SMF relative to placebo (with a single treatment comprising up to 50 injections, and up to six treatments given at least 1 month apart). These SMF benefits (which were measured subjectively by clinicians and recipients, as well as objectively, 12 weeks after the last treatment session) generally occurred without detriment to skin laxity and were largely maintained over extended follow-up (e.g. 2 years after treatment). Deoxycholic acid injections are generally well tolerated, with adverse events usually involving the treatment area, being mild to moderate in severity and resolving within approximately one treatment interval. However, not all patients with SMF may be suitable for deoxycholic acid therapy, making patient selection key to achieving desired aesthetic outcomes. Thus, deoxycholic acid injections are an effective and generally well tolerated, minimally invasive option for the treatment of moderate to severe SMF in select adults.
机译：脱氧胆酸是参与饮食脂肪乳化/增溶的仲胆汁酸，当注入皮下脂肪组织时会引起脂肪细胞溶解。合成脱氧胆酸（Kybella（TM）; Belkyra（TM））的注射溶液浓度为10 mg / mL，已在包括美国在内的多个国家/地区以及欧洲/欧盟范围内的多个国家/地区使用，以改善中度至严重的凸度或丰满度与成人的mentalmental submental fat（SMF）相关，目前是唯一批准的下巴下方脂肪治疗方法。在这种情况下进行的多个III期试验中，相对于安慰剂，向SMF中注射2 mg / cm（2）的脱氧胆酸可降低中度至重度SMF的凸度/饱满度（一次治疗最多可注射50次，间隔至少1个月进行六次治疗）。这些SMF益处（由临床医生和接受者主观评估，并且在最后一次治疗后12周客观地进行了评估）通常在不损害皮肤松弛的情况下发生，并且在延长的随访期（例如治疗后2年）中得到了很大程度的维持。脱氧胆酸注射液通常具有良好的耐受性，不良事件通常涉及治疗区域，轻度至中度严重，可在大约一个治疗间隔内解决。但是，并非所有患有SMF的患者都可能适合脱氧胆酸治疗，这使患者选择对于实现所需的美学效果至关重要。因此，脱氧胆酸注射液是一种有效且通常耐受性良好的微创疗法，可用于治疗某些成年人的中重度SMF。

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